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J. Kim, H. Ishikawa, J. Xu, G. Wollstein, R. A. Bilonick, L. Kagemann, J. S. Schuman; Normalization of Time Domain Optical Coherence Tomography (TD-OCT) Retinal Nerve Fiber Layer (RNFL) Thickness Measurements at Variable Scan Locations to a Virtual Universal Center Location Using Three-Dimensional (3D) Spectral Domain (SD-) OCT Data. Invest. Ophthalmol. Vis. Sci. 2010;51(13):211. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To develop and test a method of normalizing TD-OCT RNFL thickness measurements obtained at variable scan locations to a virtual universal center location using a retinal nerve fiber bundle distribution (RNFBD) pattern detected on the corresponding 3D SD-OCT images.
Twelve eyes of 12 healthy subjects and 7 eyes of 7 glaucoma subjects were enrolled. A set of nine TD-OCT (Stratus OCT; Carl Zeiss Meditec, Inc., Dublin, CA (CZMI)) circumpapillary scans (one centered and 8 intentionally off-centered) were obtained for each eye. One 3D SD-OCT (Cirrus HD-OCT; CZMI) optic nerve head cube scan was also obtained at the same visit. RNFBD pattern was modeled by detecting the major RNFBD curvatures (one for each in superior and inferior hemi-field) on a SD-OCT cube data for each eye. RNFL thickness measurements from off-centered TD-OCT scans were normalized by using the modeled RNFBD pattern and the matched scan location within the corresponding SD-OCT cube data. Algorithm performance was assessed by comparing global and sectoral RNFL thickness measurement imprecisions with and without normalization.
RNFL thickness measurement imprecision was statistically significantly lower with normalization than without in all sectors except for global mean (Figure).
The developed normalization method reduced the RNFL thickness measurement variability caused by variable scan locations. This method may be useful for longitudinal glaucoma progression analysis.
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