April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Interocular Asymmetry in Retinal Nerve Fiber Layer Thickness Measured With CirrusTM HD-OCT in Normal Eyes
Author Affiliations & Notes
  • D. L. Budenz
    Ophthalmology, Epidemiology & Public Health,
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida
  • J.-C. Mwanza
    Ophthalmology,
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida
  • M. Durbin
    R & D, Carl Zeiss Meditec, Inc, Dublin, California
  • Cirrus OCT Normative Database Study Group
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida
  • Footnotes
    Commercial Relationships  D.L. Budenz, Carl Zeiss Meditec, F; J.-C. Mwanza, Carl Zeiss Meditec, F; M. Durbin, Carl Zeiss Meditec, E.
  • Footnotes
    Support  Unrestricted grant from the Research to Prevent Blindness, and an unrestricted research support from Carl Zeiss Meditec, Inc.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 214. doi:https://doi.org/
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      D. L. Budenz, J.-C. Mwanza, M. Durbin, Cirrus OCT Normative Database Study Group; Interocular Asymmetry in Retinal Nerve Fiber Layer Thickness Measured With CirrusTM HD-OCT in Normal Eyes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):214. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine normal tolerance limits for interocular difference in RNFL thickness measured with Cirrus HD-OCT in normal eyes.

Methods: : Two hundred and eighty-four normal subjects were included in the study. Both eyes of each participant were scanned with Cirrus HD-OCT using the Optic Disc 200x200 protocol. Interocular differences were calculated for average, quadrants and clock-hours RNFL thickness. Normal ranges for interocular differences were established as the 2.5th and 97.5th percentiles. The correlation between interocular difference in average RNFL thickness and demographic/ocular characteristics was assessed with the Pearson correlation coefficient. Multiple regression analysis was used to determine the best predictor of interocular difference in average RNFL thickness.

Results: : The average RNFL in OD was 0.5 µm thicker than in OS; the difference was marginally significant (p = 0.049). All quadrants showed statistically significant interocular differences in RNFL thickness (p < 0.05). The temporal, nasal and inferior quadrants had thicker RNFL in OD whereas OS showed thicker RNFL in the superior quadrant. Except for clock-hours 4, 5 and 6, all other clock-hours showed statistically significant interocular differences in RNFL thickness. The RNFL was thicker in 7 of the clock-hours in OD and 2 (clock-hours 12 and 1) in OS. The 2.5th and 97.5th percentiles interocular difference tolerance limits for average RNFL thickness were -7.9 µm and 8.1 µm, respectively. Average RNFL thickness correlated well in both eyes (r = 0.89, p < 001). The difference in average RNFL thickness correlated with differences in axial length (r = -0.229, p < 0.01), disc area (r = 0.213, p < 0.01), cup-to-disc ratio (r = 0.145, p = 0.014), and vertical cup-to-disc ratio (r = 0.152, p = 0.01). However, only differences in axial length (p < 0.01) and disc area (p < 0.01) predicted the interocular variability of average RNFL thickness.

Conclusions: : An interocular difference in average RNFL thickness exceeding 8 µm when measured with Cirrus HD-OCT in normal eyes may be considered as abnormal asymmetry, and may indicate early glaucomatous damage.

Keywords: imaging/image analysis: clinical 
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