April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Quantitative Measurements of Retinal Nerve Fiber Layer (RNFL) Thickness Decay Along the Retinal Nerve Fiber Bundle Path (RNFBP) With Three-Dimensional (3D) Spectral Domain Optical Coherence Tomography (SD-OCT)
Author Affiliations & Notes
  • J. Xu
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology & Visual Science Research Center, Dept. of Ophthalmology, Univ. of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • H. Ishikawa
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology & Visual Science Research Center, Dept. of Ophthalmology, Univ. of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, Univ. of Pittsburgh, Pittsburgh, Pennsylvania
  • R. A. Bilonick
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology & Visual Science Research Center, Dept. of Ophthalmology, Univ. of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Biostatistics, Graduate School of Public Health, Univ. of Pittsburgh, Pittsburgh, Pennsylvania
  • G. Wollstein
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology & Visual Science Research Center, Dept. of Ophthalmology, Univ. of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • M. L. Gabriele
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology & Visual Science Research Center, Dept. of Ophthalmology, Univ. of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, Univ. of Pittsburgh, Pittsburgh, Pennsylvania
  • Y. Ling
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology & Visual Science Research Center, Dept. of Ophthalmology, Univ. of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Biostatistics, Graduate School of Public Health, Univ. of Pittsburgh, Pittsburgh, Pennsylvania
  • J. S. Kim
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology & Visual Science Research Center, Dept. of Ophthalmology, Univ. of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, Univ. of Pittsburgh, Pittsburgh, Pennsylvania
  • L. S. Folio
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology & Visual Science Research Center, Dept. of Ophthalmology, Univ. of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, Univ. of Pittsburgh, Pittsburgh, Pennsylvania
  • L. Kagemann
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology & Visual Science Research Center, Dept. of Ophthalmology, Univ. of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, Univ. of Pittsburgh, Pittsburgh, Pennsylvania
  • J. S. Schuman
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology & Visual Science Research Center, Dept. of Ophthalmology, Univ. of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, Swanson School of Engineering, Univ. of Pittsburgh, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships  J. Xu, Bioptigen, Inc., P; H. Ishikawa, Bioptigen, Inc., P; R.A. Bilonick, None; G. Wollstein, Carl Zeiss Meditec, Inc., F; Optovue, F; Bioptigen, Inc., P; M.L. Gabriele, None; Y. Ling, None; J.S. Kim, None; L.S. Folio, None; L. Kagemann, None; J.S. Schuman, Bioptigen, Inc., P; Carl Zeiss Meditec, Inc., P; Carl Zeiss Meditec, Inc., R; Heidelberg Engineering, Inc., R; Pfizer, R.
  • Footnotes
    Support  NIH R01-EY013178-9, P30-EY008098; Eye and Ear Foundation (Pittsburgh, PA); Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 220. doi:https://doi.org/
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    • Get Citation

      J. Xu, H. Ishikawa, R. A. Bilonick, G. Wollstein, M. L. Gabriele, Y. Ling, J. S. Kim, L. S. Folio, L. Kagemann, J. S. Schuman; Quantitative Measurements of Retinal Nerve Fiber Layer (RNFL) Thickness Decay Along the Retinal Nerve Fiber Bundle Path (RNFBP) With Three-Dimensional (3D) Spectral Domain Optical Coherence Tomography (SD-OCT). Invest. Ophthalmol. Vis. Sci. 2010;51(13):220. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

Previously we reported the RNFL thickness decay along straight radial lines without taking the natural curvature of the RNFBP. The purpose of this study was to revisit the RNFL thickness decay measurements along the individual RNFBP pattern on 3D SD-OCT images.

 
Methods:
 

Forty-six eyes of 46 healthy subjects were scanned with 3D SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA; ONH Cube 200x200 scan protocol). Two major RNFBPs (superior and inferior) were manually traced as two parabolic curves passing the disc center on two-dimensional RNFL thickness maps generated from 3D SD-OCT images. RNFBPs in the remaining area were automatically generated by interpolating the major RNFBP curve in either superior or inferior hemi-field assuming the horizontal meridian was a straight line. RNFL thickness was then re-sampled along RNFBPs at 1 degree interval (total 360 RNFBPs).

 
Results:
 

NFL thickness data showed consistent characteristics across all subjects: a plateau of high NFL thickness was seen near the disc margin in inferior quadrant, while NFL thickness decayed without a plateau in the superior, temporal and nasal quadrants, just like the previously reported results sampled along the straight radial lines (Figure). Linear model was used to fit the decay. In the pair-wise comparison, RNFL decay slopes were statistically significantly different to each others in 4 quadrants except for nasal comparing with superior quadrants.

 
Conclusions:
 

RNFL decay characteristics were confirmed with the new model along the individual RNFBP. This method may permit advanced research about spatial progression of glaucomatous damage.  

 
Keywords: imaging/image analysis: non-clinical • image processing • nerve fiber layer 
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