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J.-C. Mwanza, J. D. Oakley, D. R. Anderson, D. L. Budenz; Ability of CirrusTM HD-OCT Optic Disc Measurements to Discriminate Between Normal and Glaucomatous Eyes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):224.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the ability of measurements of optic disc parameters with Cirrus HD-OCT to discriminate between normal and glaucomatous eyes.
Seventy-three glaucomatous patients and 146 age-matched normal subjects were included in the study. For each participant, one randomly selected eye was scanned using the Optic Disc Cube 200x200 protocol. The parameters that were measured were the disc area, rim area, cup-to-disc area ratio (CDR), vertical cup-to-disc ratio (VCDR), horizontal cup-to disc ratio (HCDR), vertical rim thickness (VRT), horizontal rim thickness (HRT), and cup volume. Measurements were automatically generated by a Carl Zeiss Meditec ONH analysis algorithm developed for Cirrus HD-OCT (version 5.0). Receiver operating characteristics (ROC) curves were used to describe the ability to discriminate between normal and glaucomatous eyes and between glaucoma subgroups. The diagnostic performance of each parameter was assessed by reporting the area under receiver operating characteristics (AUC).
VRT (AUC = 0.963), rim area (0.962), VCDR (0.951), CDR (0.930) and HRT (0.901) showed excellent ability to discriminate normal from glaucomatous eyes, regardless of disease stage. Except for disc area (0.60), all other parameters also had excellent ability to differentiate normal eyes from eyes with moderate to advanced glaucoma (range: 0.92-1.0). VRT (0.914) and rim area (0.912) showed the highest ability to discriminate healthy eyes from eyes with early glaucoma, followed by VCDR, CDR, HRT, cup volume, and HCDR (range: 0.821-0.89). VCDR (0.801) outperformed other parameters for separating eyes with early glaucoma and those with moderate glaucoma. None of the parameters showed a good ability to differentiate moderate from advanced glaucoma (range: 0.497-0.686). The AUCs of all parameters, except for disc area, decreased gradually from discriminating between normal eyes and eyes with moderate to severe glaucoma, normal eyes and all glaucomatous eyes, discriminating between normal from eyes with mild glaucoma, eyes with mild from eyes with moderate glaucoma and eyes with moderate glaucoma from those with severe glaucoma.
Optic disc parameters measured with Cirrus HD-OCT showed good to excellent ability to discriminate between normal and glaucomatous eyes irrespective of disease stage, normal from moderate to severe glaucoma, and normal from early glaucoma.
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