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M. Kim, G. An, K. Park, D. Kim, T.-W. Kim; Reproducibility of Peripapillary Retinal Nerve Fiber Thickness Measurement With Spectral Domain OCT(Spectralis) in Glaucomatous Eyes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):231.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the reproducibility of Spectralis optical coherence tomography (OCT) peripapillary retinal nerve fiber layer (RNFL) measurements in eyes with the spectrum of glaucomatous visual field loss.
One eye from 63 stable glaucoma patients with a range of severity was imaged with spectral domain OCT (Spectralis; Heidelberg Engineering, Heidelberg, Germany) 6 times on 2 separate visits within 1 week (3 times on each visit) to determine intravisit and intervisit variability. Patients were divided into 3 groups according to the visual field mean deviation (MD) value; early (MD >-6, n=25), moderate (-12<MD≤-6, n=19) and advanced (MD≤-12, n=19) glaucoma groups. Intraclass correlation coefficient (ICC), coefficient of variation (CV) and test-retest variability was determined and compared between the groups.
The ICC for average RNFL measurement were 0.99, 0.97 and 0.99 in early, moderate and advanced glaucoma groups and the CV ranged from 1.4 to 4.0 %. For average RNFL thickness, the intravisit test-retest variabilities were 2.51 [confidence interval (CI), 1.96-3.49], 3.43 (CI, 2.59-5.07) and 4.04 (CI, 3.05-5.97) µm and the intervisit variabilities were 2.63 (CI, 2.05-3.66), 4.87 (CI, 3.68-7.20) and 4.16 (CI, 3.14-6.15) µm in early, moderate and advanced glaucoma groups, respectively.
The reproducibility of spectralis OCT for RNFL thickness is excellent in all glaucomatous eyes with different severity of visual field loss.
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