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T.-W. Kim, E. Lee, M. Kim, K. Park, D. Kim; Evaluation of OCT GPA in Eyes With Stable and Progressive Glaucomatous Eyes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):233.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness measurement for glaucoma progression analysis (GPA) in eyes with stable and progressive glaucomatous eyes.
Eighty two eyes from 82 glaucoma patients with localized RNFL defect who were followed up at least 36 months and had received at least 4 red-free photography and Stratus OCT were included. Patients were divided into 3 groups based on the serial red-free photography findings; stable glaucoma group (group 1), patients who showed episodic progression (group 2), and patients who showed continuous progression (group 3). The rate of deterioration for global average, quadrant and clock hour RNFL thicknesses was compared between the groups.
Group 3 showed significantly faster rate of OCT RNFL thickness deterioration than group 1 for the clock hour sectors (-4.27 microm/year vs -1.31 microm/year, P=0.004) and quadrants (-2.73 microm/year vs -0.92 microm/year, P=0.019) where progressive change was defined by red-free photography. For global average thickness, the rate of deterioration was not significantly different between groups.
OCT GPA appears to be useful to detect progressive RNFL loss in eyes with glaucoma.
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