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B. Monsalve, A. Ferreras, A. B. Pajarin, L. E. Pablo, J. L. Urcelay; Reproducibility of Retinal Nerve Fiber Thickness Measurements Using Spectral-Domain Optical Coherence Tomography in Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2010;51(13):242.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the reproducibility of retinal nerve fiber layer (RNFL) parameters acquired with optical coherence tomography (OCT) in eyes with perimetric glaucoma.
Ninety-five consecutive glaucoma patients were prospectively selected. All of them had intraocular pressure higher than 21 mmHg and abnormal standard automated perimetry. Only one eye was randomly included in the study. Each eye was scanned with spectral domain OCT (Spectralis; Heidelberg Engineering, Heidelberg, Germany) three times on the same day. The same operator performed all scans with the same device, and all images were acquired using the Spectralis eye-tracking system. Intraclass correlation coefficient (ICC), coefficient of variation (COV), and test-retest variability were calculated for the peripapillary RNFL parameters.
Mean age was 62.4±7.1 years and mean deviation of standard automated perimetry was -5.0 ±5.7 dB. The ICC was higher than 0.94 for all parameters. The COV ranged from 2.5% (global RNFL) to 6.5% (temporal quadrant). Test-retest variability was lower than 10 µm for all variables. The global RNFL had the highest ICC (0.992) and the lowest test-retest variability (3.8 µm).
The reproducibility of Spectralis OCT for peripapillary RNFL thickness was sufficiently good to be useful for improving early diagnosis and monitoring progression in glaucoma patients.
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