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L. Gil-Arribas, A. Ferreras, P. Calvo, A. B. Pajarin, L. E. Pablo, V. Polo; Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness Measured by Cirrus and Stratus Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2010;51(13):259.
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© ARVO (1962-2015); The Authors (2016-present)
To study the agreement between peripapillary retinal nerve fiber layer (RNFL) thickness measured by time domain (Stratus) and spectral domain (Cirrus) optical coherence tomography (OCT) in open-angle glaucoma patients.
A total of 56 glaucoma subjects were analyzed. Only one eye was randomly included in the study. All of them had intraocular pressure higher than 21 mmHg and abnormal standard automated perimetry.Peripapillary RNFL thickness was measured with Stratus (Fast RNFL thickness 3.46 mm scan protocol) and Cirrus (Optic Disc Cube 200 x 200 scan protocol) on the same visit. Left eye data were converted to a right eye format. Student paired t tests and Pearson’s correlation coefficients of the RNFL thickness measurements were calculated between both devices.
Mean age was 63.5±7.8 years and mean deviation of standard automated perimetry was -5.4±5.5 dB. All RNFL parameters showed significant correlations between both instruments, except for the average thickness (p=0.580). The strongest correlations were observed for inferior quadrant thickness (0.920, p>0.001), RNFL thickness at the 7 o'clock position (0.906, p<0.001), and RNFL thickness at 10 o'clock position (0.897, p<0.001). Mean RNFL thicknesses at 2 o'clock position, 3 o'clock position and nasal quadrant were significant different (paired t test, p<0.001) when comparing Stratus and Cirrus measurements.
In general, there was a good agreement between Stratus and Cirrus OCT data in glaucoma patients. Nevertheless, there are differences that must be taken into account in clinical practice.
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