April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Correlation of the Structural Changes from Spectral-Domain Optical Coherence Tomography and Fundus Autofluorescence With Visual Function in Retinitis Pigmentosa
M. A. Ibrahim; R. Channa; Q. Nguyen; A. Bittner
Author Affiliations & Notes
  • M. A. Ibrahim
    Ophthalmology, Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • R. Channa
    Ophthalmology, Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Q. Nguyen
    Ophthalmology, Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • A. Bittner
    Ophthalmology, Lions Vision Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  M.A. Ibrahim, None; R. Channa, None; Q. Nguyen, Heidelberg Inc., F; A. Bittner, None.
  • Footnotes
    Support  Mohamed A. Ibrahim is a recipient of a research fellowship from the Egyptian Ministry of Higher Education and the Arnall Patz Research Grant Award from Wilmer Eye institute.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 273. doi:
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      M. A. Ibrahim, R. Channa, Q. Nguyen, A. Bittner; Correlation of the Structural Changes from Spectral-Domain Optical Coherence Tomography and Fundus Autofluorescence With Visual Function in Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2010;51(13):273.

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Abstract

Purpose: : To correlate structural changes detected with spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (AF) with the visual function changes in patients with retinitis pigmentosa (RP).

Methods: : SD-OCT scans and AF images were acquired from 62 eyes without macular edema (34 patients; mean age 48 ±15.9 years) with varying durations of RP (mean = 26.6±19 years) using Spectralis HRA+OCT® (Heidelberg Inc. Vista, CA). Functional tests included logMAR visual acuity, VA; and Pelli-Robson contrast sensitivity; CS. Retinal thickness (RT) was calculated for 13 subfields (C, T2, T3, T6, S2, S3, S6, N2, N3, N6, I2, I3, and I6; C = Central, T = Temporal, S = Superior, N = Nasal, I = Inferior within central 1, 2, 3, and 6mm circles). RT in C was correlated to VA in all subjects. RT was compared to data from normally sighted individuals (n = 108). AF images were correlated qualitatively with OCT, Goldmann visual field, VF; and disease duration.

Results: : Average RT ranged between 210µm (SD ±27) in T6 and 283 (SD ±39) in T3. RT measurements were statistically and significantly (p < 0.05) lower than corresponding subfields in normal subjects with greatest loss in T6 (26%) followed by S6 (25%); smallest loss in N2 (16%) and C (16%). Average VA and CS were 0.42 (SD ±0.47) and 1.09 (SD ±0.59) respectively. RT in C showed correlation to VA (r = 0.48; p< 0.01) and better correlation to CS (r = 0.77; p < 0.01). Loss of AF correlated with VF loss and with OCT findings of attenuated photoreceptor (PR) and retinal pigment epithelial (RPE) cells. Extent of AF loss corresponded to duration of disease across subjects. The most common AF pattern was development of perifoveal hyperfluorescent ring early in the disease course and a perifoveal ring of lost AF in subjects with longer disease duration.

Conclusions: : RT loss in RP patients as detected by SD-OCT is due to loss of PR and RPE cells. CS has better correlation than VA to structural loss in central retina. Detection of perifoveal ring of increased AF in early RP may have important implications for development of future VA and CS loss.

Keywords: inner retina dysfunction: hereditary • photoreceptors • imaging/image analysis: clinical 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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