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H. Koizumi, T. Yamagishi, R. Kawasaki, S. Kinoshita; Subfoveal Choroidal Thickness in Typical Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):278.
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To investigate the subfoveal choroidal thickness in eyes with typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) using enhanced depth imaging optical coherence tomography (EDI OCT).
This study involved 46 eyes of 44 patients (12 females and 32 males) with typical AMD or PCV. Cross-sectional images of the choroid of each of the involved eyes were obtained by spectral-domain OCT. The choroidal thickness under the fovea was retrospectively studied.
Of the 46 eyes involved in this study, 21 eyes were diagnosed as typical AMD and the other 25 eyes were diagnosed as PCV. The difference in subfoveal choroidal thickness between the eyes with typical AMD (247µm) and those with PCV (294µm) was statistically significant, even after adjusting for age, spherical equivalent, and gender distribution (P<0.05). However, when we excluded the eyes with choroidal vascular hyperpermeability seen by indocyanine green angiography (2 eyes with typical AMD and 8 eyes with PCV), the difference was not statistically significant (typical AMD: 238µm; PCV: 263µm; P=0.35). When compared to persons with choroidal thickness <300µm, persons with chroidal thickness >= 300µm were 5.7 times more likely to be with PCV (Adjusted odds ratio 5.7, 95% confidence interval 1.3-24.6, p=0.02).
In this study, the choroid under the fovea was thicker in eyes with PCV than in eyes with typical AMD. However, the higher frequency of choroidal vascular hyperpermeability in the PCV eyes might have influenced the results.
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