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A. Henaine-Berra, D. Moreno-Paramo, J. Jiménez-Sierra, J. J. Fromow-Guerra; Stargardt Disease Retinal Analysis With Fourier-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2010;51(13):317.
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To describe retinal changes observed by Fourier-Domain Optical Coherence Tomography (OCT) in patients with Stargardt disease.
Descriptive, transversal study. Patients with clinical diagnosis of Stargardt disease confirmed by means of fluorescein angiography and electrophysiology studies were included. All patients underwent a complete ophthalmological examination and best corrected visual acuity assessment. A Fourier-domain OCT of the macular area (Cirrus HD OCT, Zeiss) was performed in all cases, using a 512x128 macular cube. The central macular thickness (CMT), the structural characteristics of the retina and retinal pigment epithelium (EPR) were analyzed.
Thirty-eight eyes of 19 patients (9 male, 10 female) were included. Age ranged from 12 to 51 years. Mean CMT: 173.96 µm. OCT findings showed RPE irregularities in 29 eyes (76.31%), photoreceptor layer loss in 23 eyes (60.53%), inner retinal layer disorganization in 12 eyes (31.58%), increased visualization of choroidal vessels in 16 eyes (42.10%), hyper-reflective intraretinal deposits in 12 eyes (31.58%) and macular atrophy in 9 eyes (23.68%). Foveal Thinning (<200µm) was observed in 28 eyes (73.68%) which correlates with mean BCVA of 20/200.
Our results suggest that the Fourier domain OCT could be a useful tool in the analysis of the atrophy extent in the RPE-photoreceptor complex and its relation with the choriocapillaris in patients with Stargardt disease.
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