April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Stargardt Disease Retinal Analysis With Fourier-Domain Optical Coherence Tomography
Author Affiliations & Notes
  • A. Henaine-Berra
    Ophthalmology, Asociacion Para Evitar la Ceguera, Mexico, Mexico
  • D. Moreno-Paramo
    Retina, Association Para Evitar la Ceguera, Mexico, Mexico
  • J. Jiménez-Sierra
    Ophthalmology, Asociacion Para Evitar la Ceguera, Mexico, Mexico
  • J. J. Fromow-Guerra
    Retina, Association Para Evitar la Ceguera, Mexico City, Mexico
  • Footnotes
    Commercial Relationships  A. Henaine-Berra, None; D. Moreno-Paramo, None; J. Jiménez-Sierra, None; J.J. Fromow-Guerra, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 317. doi:
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      A. Henaine-Berra, D. Moreno-Paramo, J. Jiménez-Sierra, J. J. Fromow-Guerra; Stargardt Disease Retinal Analysis With Fourier-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2010;51(13):317.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To describe retinal changes observed by Fourier-Domain Optical Coherence Tomography (OCT) in patients with Stargardt disease.

Methods: : Descriptive, transversal study. Patients with clinical diagnosis of Stargardt disease confirmed by means of fluorescein angiography and electrophysiology studies were included. All patients underwent a complete ophthalmological examination and best corrected visual acuity assessment. A Fourier-domain OCT of the macular area (Cirrus HD OCT, Zeiss) was performed in all cases, using a 512x128 macular cube. The central macular thickness (CMT), the structural characteristics of the retina and retinal pigment epithelium (EPR) were analyzed.

Results: : Thirty-eight eyes of 19 patients (9 male, 10 female) were included. Age ranged from 12 to 51 years. Mean CMT: 173.96 µm. OCT findings showed RPE irregularities in 29 eyes (76.31%), photoreceptor layer loss in 23 eyes (60.53%), inner retinal layer disorganization in 12 eyes (31.58%), increased visualization of choroidal vessels in 16 eyes (42.10%), hyper-reflective intraretinal deposits in 12 eyes (31.58%) and macular atrophy in 9 eyes (23.68%). Foveal Thinning (<200µm) was observed in 28 eyes (73.68%) which correlates with mean BCVA of 20/200.

Conclusions: : Our results suggest that the Fourier domain OCT could be a useful tool in the analysis of the atrophy extent in the RPE-photoreceptor complex and its relation with the choriocapillaris in patients with Stargardt disease.

Keywords: retinal degenerations: hereditary • retina • imaging/image analysis: clinical 
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