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E. Lindner, A. Weinberger, T. Kirschkamp, Y. El-Shabrawi, A. Barounig; Near-Infrared Autofluorescence and Indocyanine Green Angiography in Chronic Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):318.
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To compare the results of near-infrared (NIR) autofluorescence (AF) and indocyanine green (ICG) angiograms in central serous chorioretinopathy (CSC).
Observational case study in patients with CSC. NIR autofluorescence and ICG angiograms (excitation 787nm; emission >800nm) were recorded with a confocal scanning laser ophthalmoscope. Gray value relations (ROI/adjacent area) were compared. 21 eyes of 19 patients (mean age 41.09 years) were included.
In 18 of 19 feasible examinations lesions were observed with NIR-AF (94.74%). Fluorescent phenomenons were observed at the leakage site in 18 cases and in the area of serous retinal detachment in 3 cases. Mean gray value relation was 0.55±0.22 for the leakage site and 1.33±0.38 for the area of serous retinal detachment. In 21 of 21 examinations lesions were observed with ICG-angiograms. Fluorescent phenomenons could be demonstrated in 10 cases only at the leakage site, in 1 case only in the area of serous retinal detachment and in 10 cases at both sites. Mean gray value relation was 2.28±1.97 for the leakage site and 0.98±0.36 for the area of serous retinal detachment.
With near-infrared wavelength autofluorescent phenomenons failed to demonstrate CSC only in 5.26%. Considering the medical hazards and economic implications of angiography, near-infrared autofluorescence may be a non-invasive alternative to monitor CSC.
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