April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
The RPE in Multiple Evanescent White Dot Syndrome Examined With Fundus Autofluorescence, Near-Infrared Autofluorescence and Spectral Domain OCT
Author Affiliations & Notes
  • S. Kellner
    AugenZentrum Siegburg, Retina Science, Siegburg, Germany
  • S. Weinitz
    AugenZentrum Siegburg, Retina Science, Siegburg, Germany
  • U. Kellner
    AugenZentrum Siegburg, Retina Science, Siegburg, Germany
  • Footnotes
    Commercial Relationships  S. Kellner, None; S. Weinitz, None; U. Kellner, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 325. doi:
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      S. Kellner, S. Weinitz, U. Kellner; The RPE in Multiple Evanescent White Dot Syndrome Examined With Fundus Autofluorescence, Near-Infrared Autofluorescence and Spectral Domain OCT. Invest. Ophthalmol. Vis. Sci. 2010;51(13):325.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the RPE in the active stage and the recovery stage of multiple evanescent white dot syndrome (MEWDS) using different retinal imaging methods.

Methods: : Two patients with MEWDS underwent retinal imaging using fundus autofluoresence (FAF; excitation 480 nm, barrier filter 500 nm) and near-infrared autofluorescence (NIA; excitation 787 nm, barrier filter 800 nm) using a confocal scanning laser ophthalmoscope (HRA2, Heidelberg Engineering, Heidelberg, Germany) as well as spectral domain OCT (sdOCT; Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany).

Results: : In the acute stage of MEWDS, granular foveal changes correspond to markedly reduced NIA intensity and an interruption of the photoreceptor inner/outer segment layer in the sdOCT, whereas FAF alterations where limited. In contrast, the white flecks in the macula and mid-periphery can be better identified with FAF compared to NIA. FAF identifies several more flecks than are ophthalmoscopically visible. These flecks correspond to a small interruption in the photoreceptor inner/outer segment layer. During follow-up, foveal and peripheral structural integrity is reconstituted over a period of several months.

Conclusions: : MEWDS affects the RPE and the photoreceptor inner/outer segment layer in the acute stage with reconstitution of the structural damage during the recovery phase. The resolution of FAF and NIA alterations indicates, that there is a limited change of RPE cell function, but no permanent damage to the RPE.

Keywords: retinal pigment epithelium • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • inflammation 
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