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S.-E. Chung, S. Kang, K. Bae; Angiographic Finding in Fellow Eyes of Patients With Unilateral Active Polypoidal Choroidal Vasculopathy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):331.
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To investigate vascular changes on indocyanine green angiography (ICGA) in the fellow eyes of patients with unilateral active polypoidal choroidal vasculopathy (PCV).
We reviewed the medical records of 66 patients with unilateral active PCV, all of whom had undergone at least 12 months of follow-up. In the ICGA using a confocal laser scanning system, we evaluated choroidal vessel dilation and choroidal vascular hyperpermeability in the fellow eye. The incidence of late geographic hyperfluorescence (LGH), defined as a well-demarcated geographic hyperfluorescent lesion on late phase ICGA, was also assessed. The natural course of vascular lesions on ICGA and the development of active PCV over time were evaluated in the fellow eyes.
The average age of those 66 patients (54 [81.8%] were males; and 12 [18.2%] were females) at the initial examination was 66.8 ± 6.9 years. Nineteen of 66 patients (28.8%) had a history of systemic hypertension. The mean follow-up period was 21.2 ± 13.9 months. Among 66 fellow eyes, 35 eyes (53.0%) had choroidal vascular dilation, 39 eyes (59.1%) had choroidal vascular hyperpermeability, and 32 eyes (48.5%) had LGH. Fourteen fellow eyes (21.2%) developed active PCV during the follow-up period. At the initial presentation, LGH was noted in all 14 fellow eyes; however, LGH was only noted in 19 (36.5%) of the 52 fellow eyes which had not developed active PCV (P<0.001).
Chorodal vascular abnormalities are frequently found in the fellow eye of unilateral active PCV, and this phenomenon may have pathophysiologic implications. The presence of late geographic hyperfluorescence on ICGA in the fellow eye seems to be a significant risk factor for the development of active PCV.
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