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U. Karaca, U. Erdem, H. Ay, G. Ozge, K. Smsek; Use of Hyperbaric Oxygen Therapy in Restoration of Structural and Functional Integrity of the Cornea and the Conjunctiva After Severe Alkaline Injury. Invest. Ophthalmol. Vis. Sci. 2010;51(13):361.
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© ARVO (1962-2015); The Authors (2016-present)
To present the effectiveness of hyperbaric oxygen therapy (HBO) in the treatment of severe alkaline injury, and in the prevention of its long-term complications in the cornea and the external ocular surface.Material and
Twenty-seven eyes of 21 patients presented to our hospital within 2 days after severe alkaline injury (grade 4 Dua 2001) were included in the study. Patients were underwent to HBO therapy ( 2.4 ATA , %100 oxygen saturation, 1 hour exposure time) for 14 days after presentation to the hospital. Doxycycline, 20mg/day for 14 days, and prednisolone, 1 mg/kg/day in tapering doses for 21 days, were co-administered. Structural and functional integrity of the ocular surface were evaluated by serial photographs in the early period and, and clinical and laboratory testing in the late period.
Mean follow up was 11±5.6 months (range 3 to24 months). Re-epithelization is completed within 3 weeks of the therapy in 26 eyes (96.2%). HBO therapy was stopped in a case complicating severe wide scleral necrosis in the inferior fornix . No structural and functional abnormalities including recurrent corneal erosions, dry eye, or symblapharon formation were noted in successfully treated patients.
With these outstanding results, institution of HBO together with doxcycline and prednisolone seems to be a novel treatment option in cases with severe alkaline injury.
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