April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Use of Hyperbaric Oxygen Therapy in Restoration of Structural and Functional Integrity of the Cornea and the Conjunctiva After Severe Alkaline Injury
Author Affiliations & Notes
  • U. Karaca
    Ophtalmology,
    Gulhane Miltary Medical Academy, Ankara, Turkey
  • U. Erdem
    Ophtalmology,
    Gulhane Miltary Medical Academy, Ankara, Turkey
  • H. Ay
    Undersea and Hyperbaric Medicine,
    Gulhane Miltary Medical Academy, Ankara, Turkey
  • G. Ozge
    Ophtalmology,
    Gulhane Miltary Medical Academy, Ankara, Turkey
  • K. Smsek
    Undersea and Hyperbaric Medicine,
    Gulhane Miltary Medical Academy, Ankara, Turkey
  • Footnotes
    Commercial Relationships  U. Karaca, None; U. Erdem, None; H. Ay, None; G. Ozge, None; K. Smsek, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 361. doi:
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      U. Karaca, U. Erdem, H. Ay, G. Ozge, K. Smsek; Use of Hyperbaric Oxygen Therapy in Restoration of Structural and Functional Integrity of the Cornea and the Conjunctiva After Severe Alkaline Injury. Invest. Ophthalmol. Vis. Sci. 2010;51(13):361.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To present the effectiveness of hyperbaric oxygen therapy (HBO) in the treatment of severe alkaline injury, and in the prevention of its long-term complications in the cornea and the external ocular surface.Material and

Methods: : Twenty-seven eyes of 21 patients presented to our hospital within 2 days after severe alkaline injury (grade 4 Dua 2001) were included in the study. Patients were underwent to HBO therapy ( 2.4 ATA , %100 oxygen saturation, 1 hour exposure time) for 14 days after presentation to the hospital. Doxycycline, 20mg/day for 14 days, and prednisolone, 1 mg/kg/day in tapering doses for 21 days, were co-administered. Structural and functional integrity of the ocular surface were evaluated by serial photographs in the early period and, and clinical and laboratory testing in the late period.

Results: : Mean follow up was 11±5.6 months (range 3 to24 months). Re-epithelization is completed within 3 weeks of the therapy in 26 eyes (96.2%). HBO therapy was stopped in a case complicating severe wide scleral necrosis in the inferior fornix . No structural and functional abnormalities including recurrent corneal erosions, dry eye, or symblapharon formation were noted in successfully treated patients.

Conclusions: : With these outstanding results, institution of HBO together with doxcycline and prednisolone seems to be a novel treatment option in cases with severe alkaline injury.

Keywords: wound healing • oxygen • cornea: epithelium 
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