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A. J. Cree, S. Foster, S. Goverdhan, S. Khandhadia, C. Osmond, A. J. Lotery; Is Chlamydia Pneumoniae Infection Associated With Age-Related Macular Degeneration (AMD)?. Invest. Ophthalmol. Vis. Sci. 2010;51(13):407.
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Inflammation is now understood to play a significant role in the aetiology of AMD. One possible model for the pathogenesis of AMD is abnormal regulation of the alternative complement pathway due to variation in the complement factor H (CFH) gene. This alternative complement pathway may be triggered by an infectious agent such as C. pneumonia. We have•investigated a possible interaction between Chlamydia pneumoniae infection and CFH genotype in the pathogenesis of AMD.•investigated a possible interaction between Chlamydia pneumoniae infection and HTRA1 genotype in the progression of AMD.MethodA cohort of plasma samples from 200 AMD patients and 100 controls from the UK were tested for C.pneumoniae IgG antibodies in the laboratory, using a micro-immunofluorescent assay, to establish previous C.pneumoniae infection. These assays were carried out blind to complement factor H and HTRA1 genotype which were then analysed alongside the assay results to establish any possible association.
To date this study found no evidence of an association between Chlamydia pneumoniae infection and AMD, irrespective of CFH genotype.ConclusionC. pnumoniae does not appear to act as a biological trigger in AMD in our UK cohort, although other bacterial agents may play a role.
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