April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Is Chlamydia Pneumoniae Infection Associated With Age-Related Macular Degeneration (AMD)?
Author Affiliations & Notes
  • A. J. Cree
    Clinical Neurosciences,
    University of Southampton, Southampton, United Kingdom
  • S. Foster
    Clinical Neurosciences,
    University of Southampton, Southampton, United Kingdom
  • S. Goverdhan
    Ophthalmology - Eye Unit, Southampton General Hospital, Southampton, United Kingdom
  • S. Khandhadia
    Clinical Neurosciences,
    University of Southampton, Southampton, United Kingdom
  • C. Osmond
    MRC Epidemiology Resource Centre,
    University of Southampton, Southampton, United Kingdom
  • A. J. Lotery
    Clinical Neurosciences,
    University of Southampton, Southampton, United Kingdom
    Ophthalmology - Eye Unit, Southampton General Hospital, Southampton, United Kingdom
  • Footnotes
    Commercial Relationships  A.J. Cree, None; S. Foster, None; S. Goverdhan, None; S. Khandhadia, None; C. Osmond, None; A.J. Lotery, None.
  • Footnotes
    Support  American Health Assistance Foundation M2007-110, Gift of Sight Appeal
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 407. doi:
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      A. J. Cree, S. Foster, S. Goverdhan, S. Khandhadia, C. Osmond, A. J. Lotery; Is Chlamydia Pneumoniae Infection Associated With Age-Related Macular Degeneration (AMD)?. Invest. Ophthalmol. Vis. Sci. 2010;51(13):407.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Inflammation is now understood to play a significant role in the aetiology of AMD. One possible model for the pathogenesis of AMD is abnormal regulation of the alternative complement pathway due to variation in the complement factor H (CFH) gene. This alternative complement pathway may be triggered by an infectious agent such as C. pneumonia. We have•investigated a possible interaction between Chlamydia pneumoniae infection and CFH genotype in the pathogenesis of AMD.•investigated a possible interaction between Chlamydia pneumoniae infection and HTRA1 genotype in the progression of AMD.MethodA cohort of plasma samples from 200 AMD patients and 100 controls from the UK were tested for C.pneumoniae IgG antibodies in the laboratory, using a micro-immunofluorescent assay, to establish previous C.pneumoniae infection. These assays were carried out blind to complement factor H and HTRA1 genotype which were then analysed alongside the assay results to establish any possible association.

Results: : To date this study found no evidence of an association between Chlamydia pneumoniae infection and AMD, irrespective of CFH genotype.ConclusionC. pnumoniae does not appear to act as a biological trigger in AMD in our UK cohort, although other bacterial agents may play a role.

Keywords: age-related macular degeneration • pathology: human • bacterial disease 
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