April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Macular Function in Early and Intermediate Age-Related Macular Degeneration: A Screening Approach
Author Affiliations & Notes
  • S. Vujosevic
    Fondazione G. B. Bietti, IRCCS, Roma, Italy
  • K. A. Lebow
    Adjunct Faculty, Pennsylvania College of Optometry Private Practice, Virginia Beach, Virginia
  • N. Notaroberto
    EyeCare 20/20, Slidell, Louisiana
  • A. Pallikaris
    Institute of Vision and Optics, University of Crete, Heraklion, Greece
  • M. Casciano
    The International Microperimetry Reading Centre, Padova, Italy
  • M. K. Smolek
    Department of Ophthalmology, LSU Eye Center, New Orleans, Louisiana
  • Footnotes
    Commercial Relationships  S. Vujosevic, None; K.A. Lebow, I, I; P, P; N. Notaroberto, R, R; A. Pallikaris, R, R; M. Casciano, None; M.K. Smolek, C, C.
  • Footnotes
    Support  Research to Prevent Blindness, Inc. (MKS); LSU Research Enhancement Fund (MKS)
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 536. doi:
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    • Get Citation

      S. Vujosevic, K. A. Lebow, N. Notaroberto, A. Pallikaris, M. Casciano, M. K. Smolek; Macular Function in Early and Intermediate Age-Related Macular Degeneration: A Screening Approach. Invest. Ophthalmol. Vis. Sci. 2010;51(13):536.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate if retinal sensitivity values obtained with a dedicated screening device can be used to screen an early and intermediate age-related macular degeneration (ARMD).

Methods: : A fully automatic fundus-perimeter combined with an image-stabilized scanning laser ophthalmoscope, Macular Integrity Assessment (MAIA, CenterVue, spa; Padova, Italy) was used in 355 ARMD patients. The standard automatic sensitivity grid (10 x 10 degrees, 61 stimulated points, centered on the fovea) was performed in 5 study sites. Fixation was simultaneously documented. Inclusion criteria were: age >50 years and AREDS 2 and 3 severity scale. Two hundred sixty five normal subjects were used as age-matched control group. Sensitivity point values (S-values), mean retinal sensitivity, number of points below 24 dB (K-value, considered as cut-off for normal values) and fixation stability were recorded. ANOVA, trend analysis, and summary statistics were calculated using Sigmaplot 11 (Systat Software, Inc; San Jose, CA).

Results: : Of 355 patients, 200 were classified as AREDS 2 and 155 as AREDS 3. S-values and summary statistics between normals and ARMD were significantly different (ANOVA; p<0.001). Mean retinal sensitivity was significantly reduced in AREDS 2 and 3 vs normals (24.85dB+3.87 and 21.76dB+5.36 vs 29.78dB+1.71, p<0.001). K-value were different between AREDS 2 and 3 (ANOVA; p<0.001). Fixation stability did not differ between AREDS 2 and 3. S-values decreased toward the periphery of the examined area and varied by meridian.

Conclusions: : Macular sensitivity is reduced in patients with early and intermediate ARMD when compared to age-matched normals. Sensitivity reduction is more relevant in intermediate than in early ARMD. These changes can be detected with a new screening device.

Keywords: age-related macular degeneration • clinical (human) or epidemiologic studies: systems/equipment/techniques • perimetry 

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