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T. T. Lam, C. Busse, J. Boehme, W. K. McVicar, N. Kim, T. McCauley, B. J. Christian; Heterogeneous Intraocular Pressure (IOP) Response After Topical Administration of Trusopt or Xalatan in Ocular Normotensive Conscious Cynomolgus Monkeys. Invest. Ophthalmol. Vis. Sci. 2010;51(13):564.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the heterogeneity and relationship of IOP-lowering response of two agents with different mechanisms of action, Trusopt, and Xalatan, in ocular normotensive conscious cynomolgus monkeys
Trusopt (2%), a carbonic anhydrase inhibitor (CAI), or Xalatan (0.005%), a prostanoid selective FP receptor agonist (PG), was applied to the right eyes of 10 ocular normotensive cynomolgus monkeys; the corresponding vehicles were applied to the left eyes. IOPs were measured in conscious animals with a pneumatonometer (Mentor Classic II) pre-dose, 2, 4, 6, 8, and up to 24 hours (mean of 3 readings per time point). Maximal IOP changes were calculated as percentages relative to predose values and relative to the left/control eye of each animal. The coefficient of correlation was calculated based on linear regression of the maximal IOP changes in response to the agents.
The following tables summarize the IOP changes and their distribution of the normotensive monkeys following topical administration of Trusopt and Xalatan.For individual animals, there was no correlation of the magnitude of IOP reduction between the two agents.
In ocular normotensive monkeys, the magnitude of IOP response to two IOP lowering agents with different modes of action (CAI, PG) is heterogeneous and shows no correlation for individual animals.
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