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R. Martin, Sr., I. Sanchez, F. Ussa, J. Pastor, J. Veciana, C. Rovira, V. Laukhin, E. Laukhina, R. Villa, J. Aguilo; Noninvasive Intraocular Pressure Monitorization With a Sensing Contact Lens. Invest. Ophthalmol. Vis. Sci. 2010;51(13):570.
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The development of a device for non-invasive monitoring of the intraocular pressure (IOP) based on a sensing contact lens (CL), which equipped with a nanostructured flexible all-organic pressure sensor.
Polycarbonate film nanostructured with an organic molecular conductor whose electric resistance is capable to detect extremely small pressure changes (lower than 1 mmHg) was used as a flexible pressure sensor. The sensor was placed over a hole fabricated on a top of a rigid gas permeable CL (Boston XO2 - Conoptica, Spain) that was designed according to the pig eye corneal parameters. The IOP is indirect measured to detect the corneal deformations due to variations of the IOP (an IOP change of 1 mm Hg causes a change of central corneal radius of curvature of approximately 3 µm). Pig eye was cannulated (23G) at 3.5 mm from the esclerocorneal limbus and connected to a water column pressure system controlled by a low-pressure transducer (Wika CPC 2000). This transducer can increase, decrease and maintain pig eye IOP. The lens was easily stuck to the cannulated pig eye with a few drops of artificial tear that makes possible IOP measurements. The electrical response of the sensor was collected with a multimeter (Agilent 34410A) and recorded in a personal computer as a function of the pig eye IOP values.
The sensor CL fits perfectly with the pig eye, allowing the creation of a simple prototype to measure the IOP of the porcine eye. The nanostructured sensor is able to detect changes of the corneal surface generated by IOP fluctuations (Figure 1) induced by low-pressure transducer.
The prototype sensory CL designed was able to detect IOP variations (around 1 mm Hg) in ex-vivo pig eye. This device showed the potential to monitoring IOP opening up new diagnostic and therapeutic methods for the future management of glaucoma.
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