April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Comparison of Two Treatment Schedules of Intravitreal Ranibizumab for Neovascular Age Related Macular Degeneration
Author Affiliations & Notes
  • O. A. Adepegba
    Ophthalmology Department, Kings College Hospital, London, United Kingdom
  • B. Gupta
    Ophthalmology, King's College Hospital NHS Trust, Ilford, United Kingdom
  • T. Adewoyin
    Ophthalmology Department, Kings College Hospital, London, United Kingdom
  • S. Patel
    Ophthalmology Department, Kings College Hospital, London, United Kingdom
  • S. Sivaprasad
    Ophthalmology, King's College Hospital, London, Essex, United Kingdom
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 71. doi:
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      O. A. Adepegba, B. Gupta, T. Adewoyin, S. Patel, S. Sivaprasad; Comparison of Two Treatment Schedules of Intravitreal Ranibizumab for Neovascular Age Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2010;51(13):71.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare the outcomes of two treatment protocols for neovascular age related macular degeneration: Loading dose (3+PRN) versus PRN dosing from baseline.

Methods: : This retrospective study assessed 78 consecutive patients (78 eyes) with visual acuity between 24 and 73 letters due to all subtypes of neovascular age related macular degeneration treated with ranibizumab and followed up for twelve months. The patients were divided into two treatment groups: I) 3+PRN consisting of three initial injections at monthly intervals followed by OCT guided retreatment and II) a pro re nata-PRN dosing schedule with OCT guided retreatment criteria from start of therapy. The main outcome measures compared in the two treatment groups were change in visual acuity (VA) and central macular thickness (CMT).

Results: : The mean VA at baseline was 48± 15.25 and 44.48 ± 15.41 ETDRS letters in the 3+prn and prn group respectively. In the 3+ prn group (n=47), 89.01% and in the prn group(n=31) 93.1% maintained stable vision. However 29% had more than 15 letter improvements in the 3+prn group compared with 12.9% in prn group (p=0.04). The mean change in VA at 12 month of +6.4 in the 3+prn and +3.9 in the prn group (p=0.35). The mean change in CMT at 12 months was -37.5 in the 3+prn and-43.5 prn group respectively (p=0.6).The mean number of ranibizumab injections was 6.0 in the 3+prn group and 4.5 in the prn group.

Conclusions: : More patients achieved visual improvement in the 3+prn group compared to the prn group, even though there was no significant difference in the CMT. This suggests the superiority of the 3+prn schedule over the prn group.

Keywords: age-related macular degeneration • visual acuity • choroid: neovascularization 
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