April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Three-Year Outcomes of Photodynamic Therapy in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Japanese Patients
Author Affiliations & Notes
  • Y. Oshima
    Ophthalmology, Kyushu University, Faculty of Medicine, Fukuoka, Japan
  • M. Yasuda
    Ophthalmology, Kyushu University, Faculty of Medicine, Fukuoka, Japan
  • K. Kano
    Ophthalmology, Kyushu University, Faculty of Medicine, Fukuoka, Japan
  • A. Yoshida
    Ophthalmology, Kyushu University, Faculty of Medicine, Fukuoka, Japan
  • S. Shiose
    Ophthalmology, Kyushu University, Faculty of Medicine, Fukuoka, Japan
  • H. Asato
    Ophthalmology, Kyushu University, Faculty of Medicine, Fukuoka, Japan
  • Y. Noda
    Ophthalmology, Kyushu University, Faculty of Medicine, Fukuoka, Japan
  • T. Ishibashi
    Ophthalmology, Kyushu University, Faculty of Medicine, Fukuoka, Japan
  • Footnotes
    Commercial Relationships  Y. Oshima, None; M. Yasuda, None; K. Kano, None; A. Yoshida, None; S. Shiose, None; H. Asato, None; Y. Noda, None; T. Ishibashi, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 74. doi:
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      Y. Oshima, M. Yasuda, K. Kano, A. Yoshida, S. Shiose, H. Asato, Y. Noda, T. Ishibashi; Three-Year Outcomes of Photodynamic Therapy in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Japanese Patients. Invest. Ophthalmol. Vis. Sci. 2010;51(13):74.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the visual outcome three years after photodynamic therapy (PDT) in patients with exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV).

Methods: : One hundred nine eyes undergoing PDT were retrospectively studied. Sixty eyes of AMD (AMD group) and forty-nine eyes of PCV (PCV group) were evaluated.

Results: : In the AMD group, the mean pre-PDT Log MAR visual acuity was 0.87. The mean post-PDT visual acuity was 1.19 after three years after PDT. Three years after PDT, the Log MAR visual acuity improved by 0.2 or more in 16 eyes (26.7%), but it decreased by 0.2 or more in 23 eyes (38.3%). In the PCV group, the mean pre-PDT Log MAR visual acuity was 0.63. The mean post-PDT visual acuity was 0.81 three years after PDT. The Log MAR visual acuity improved by 0.2 or more in 12 eyes (24.5%), but it decreased by 0.2 or more in 21 eyes (42.8%). In these two groups, the visual acuity was maintained equivalently three years after PDT (p=0.891 Χ2 test)

Conclusions: : In this series of patients, more than half of the two groups were able to maintain their visual acuity for three years after PDT. The long-term effectiveness of PDT for AMD patients is equivalent to PCV patients in Japan.

Keywords: age-related macular degeneration • photodynamic therapy • choroid: neovascularization 
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