April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Choroidal Thickness Maps Using 3D OCT at 1060nm: Variation in Healthy Eyes and Eyes With Diabetic Maculopathy
M. Esmaeelpour; B. Povaay; B. Hermann; B. Hofer; V. Kajic; S. L. Hale; K. Kapoor; R. V. North; W. Drexler; N. J. L. Sheen
Author Affiliations & Notes
  • M. Esmaeelpour
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • B. Povaay
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Center for Biomedical Engineering and Physics, Medical University Vienna, Vienna, Austria
  • B. Hermann
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Center for Biomedical Engineering and Physics, Medical University Vienna, Vienna, Austria
  • B. Hofer
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Center for Biomedical Engineering and Physics, Medical University Vienna, Vienna, Austria
  • V. Kajic
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • S. L. Hale
    Department of Ophthalmology, University Hospital of Wales, Cardiff, United Kingdom
  • K. Kapoor
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • R. V. North
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • W. Drexler
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Center for Biomedical Engineering and Physics, Medical University Vienna, Vienna, Austria
  • N. J. L. Sheen
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • Footnotes
    Commercial Relationships  M. Esmaeelpour, None; B. Povaay, None; B. Hermann, None; B. Hofer, None; V. Kajic, None; S.L. Hale, None; K. Kapoor, None; R.V. North, None; W. Drexler, is a consultant of Carl Zeiss Meditec, C; N.J.L. Sheen, None.
  • Footnotes
    Support  Cardiff University, FP6-IST-NMP-2 STREPT (017128), DTI grant (OMICRON) and AMR grant (AP1110), FP7 (FunOCT), Carl Zeiss Meditec Inc.; Diabetes UK grant BDA:RD07/003472
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1012. doi:
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      M. Esmaeelpour, B. Povaay, B. Hermann, B. Hofer, V. Kajic, S. L. Hale, K. Kapoor, R. V. North, W. Drexler, N. J. L. Sheen; Choroidal Thickness Maps Using 3D OCT at 1060nm: Variation in Healthy Eyes and Eyes With Diabetic Maculopathy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1012.

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Abstract

Purpose: : To map choroidal thickness in healthy eyes of various axial lengths and assess choroidal thickness in eyes with diabetic maculopathy.

Methods: : Axial length (AL) and 45° fundus photographs were acquired from 64 eyes (34 healthy subjects, mean±SD 42±17yrs). 1060nm-3D-OCT was performed over 36ºx36° centred on the fovea with ~7 µm axial resolution (512 A-scans/frame). Choroidal thickness (ChT) was determined between retinal pigment epithelium and the choroidal/scleral interface. Colour coded ChT- maps were segmented manually from 3D stacks. ChT from a horizontal tomogram (averaged over an area of 1500µm each side of the fovea) in 11 eyes with diabetic maculopathy (DM) (9 subjects, 58±12yrs, 23.98±0.7mm) were compared to 11 age and AL matched healthy eyes (9 subjects, 55±12yrs, 24.03±0.65mm).

Results: : ChT-maps of all healthy eyes showed thinning with increasing AL and ChT distribution across the field of view varied with AL. Mean±SD ChT at the central location was 315±106µm, negatively correlated with AL (R²=0.47, P<0.001). Averaged ChT-maps of eyes with AL<23.39mm showed the thickest choroid in an area of ~1500µm inferior to the central choroid, and eyes with AL>24.5mm had thicker choroid ~1500µm superior to the central choroid. Out of 11 DM eyes, ChT was lower in 7 eyes, equal in 2 and higher in 2 than in matched healthy eyes. ChT in DM eyes was (mean±SD) 194±66µm and 265±78µm in the healthy eyes (P<0.05, paired t-test).

Conclusions: : Choroidal maps using 1060nm-3D-OCT allow in-vivo thickness visualization in a range of ALs. Central ChT measures were found to be similar to those measured by ultrasound (Coleman et al. 2004). ChT variation with AL in healthy eyes needs to be considered when assessing diabetic maculopathy. Preliminary results suggest that this technique will be valuable in assessing choroidal changes in patients with diabetic maculopathy.

Keywords: diabetic retinopathy • choroid • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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