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B. Potsaid, J. J. Liu, V. Manjunath, T.-H. Tsai, J. S. Duker, D. Huang, J. S. Schuman, J. G. Fujimoto; Ultrahigh Speed Volumetric Ophthalmic OCT Imaging of the Retina at 800nm and 1050nm Wavelengths. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1017.
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The current generation of commercial optical coherence tomography (OCT) imaging systems have ~5 um axial resolution, use 800nm light sources, and operate at up to 52,000 axial scans per second. This investigation demonstrates the feasibility of acquiring dense 3D-OCT volumetric data sets at speeds of 70,000 to 312,500 axial scans per second at 800nm and 50,000 to 200,000 axial scans per second at 1050nm. The higher speeds promise to enable the acquisition of large and high sampling density 3D-OCT data sets with reduced eye motion for improved 3D, cross-sectional, and en face visualization of the retina.
An ultrahigh speed spectral / Fourier domain prototype OCT instrument operating at 800nm using a new high speed, line scan camera and an ultrahigh speed, swept source / Fourier domain prototype OCT instrument operating at 1050nm using new scanning laser technology were developed. The prototype instruments were used to image the macula and optic nerve head in normal subjects as well as in patients with a variety of retinal pathologies.
Dense 3D-OCT data sets obtained at high speed show minimal motion artifacts and improved image continuity in the transverse directions. Residual eye motion can be compensated through postprocessing. Cross sectional and en face images with arbitrary orientation can be extracted from the resulting data sets to investigate structure and pathology. Time dependent measurements can be performed by repeatedly acquiring volumetric data.
New spectral and swept source / Fourier domain OCT technologies enable ultrahigh speed ophthalmic OCT imaging with speeds almost an order of magnitude faster than what is typical in current commercial instruments. The prototype OCT instruments are characterized in the lab and demonstrated in the clinic for the first time to show a variety of retinal pathologies. The resulting 3D-OCT data sets provide comprehensive and high resolution visualization of the retina, which promises to improve disease detection and treatment monitoring.
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