April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Ultrahigh Speed Volumetric Ophthalmic OCT Imaging of the Retina at 800nm and 1050nm Wavelengths
B. Potsaid; J. J. Liu; V. Manjunath; T.-H. Tsai; J. S. Duker; D. Huang; J. S. Schuman; J. G. Fujimoto
Author Affiliations & Notes
  • B. Potsaid
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Inst of Technology, Cambridge, Massachusetts
    Advanced Imaging Group, Thorlabs, Inc., Newton, New Jersey
  • J. J. Liu
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Inst of Technology, Cambridge, Massachusetts
  • V. Manjunath
    New England Eye Center and Tufts Medical Center, Tufts University, Boston, Massachusetts
  • T.-H. Tsai
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Inst of Technology, Cambridge, Massachusetts
  • J. S. Duker
    New England Eye Center and Tufts Medical Center, Tufts University, Boston, Massachusetts
  • D. Huang
    Doheny Eye Institute, University of Southern CA, Los Angeles, California
  • J. S. Schuman
    UPMC Eye Center, Univ of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • J. G. Fujimoto
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Inst of Technology, Cambridge, Massachusetts
  • Footnotes
    Commercial Relationships  B. Potsaid, Thorlabs, Inc., F; Thorlabs, Inc., E; J.J. Liu, None; V. Manjunath, None; T.-H. Tsai, None; J.S. Duker, Optovue, F; D. Huang, Zeiss, P; Optovue, R; Optovue, F; Optovue, I; Optovue, C; Optovue, P; J.S. Schuman, Carl Zeiss Meditec, P; Bioptigen, P; Pfizer, R; Carl Zeiss Meditec, R; Heidelberg Engineering, R; J.G. Fujimoto, Optovue Corporation, F; Carl Zeiss Meditec, Inc, P.
  • Footnotes
    Support  NIH R01-EY011289-24, NIH R01-EY013178-10, NIH R01-EY019029-02, NIH R01-EY013516-07 and AFOSR FA9550-07-1-0101.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1017. doi:
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      B. Potsaid, J. J. Liu, V. Manjunath, T.-H. Tsai, J. S. Duker, D. Huang, J. S. Schuman, J. G. Fujimoto; Ultrahigh Speed Volumetric Ophthalmic OCT Imaging of the Retina at 800nm and 1050nm Wavelengths. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1017.

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Abstract

Purpose: : The current generation of commercial optical coherence tomography (OCT) imaging systems have ~5 um axial resolution, use 800nm light sources, and operate at up to 52,000 axial scans per second. This investigation demonstrates the feasibility of acquiring dense 3D-OCT volumetric data sets at speeds of 70,000 to 312,500 axial scans per second at 800nm and 50,000 to 200,000 axial scans per second at 1050nm. The higher speeds promise to enable the acquisition of large and high sampling density 3D-OCT data sets with reduced eye motion for improved 3D, cross-sectional, and en face visualization of the retina.

Methods: : An ultrahigh speed spectral / Fourier domain prototype OCT instrument operating at 800nm using a new high speed, line scan camera and an ultrahigh speed, swept source / Fourier domain prototype OCT instrument operating at 1050nm using new scanning laser technology were developed. The prototype instruments were used to image the macula and optic nerve head in normal subjects as well as in patients with a variety of retinal pathologies.

Results: : Dense 3D-OCT data sets obtained at high speed show minimal motion artifacts and improved image continuity in the transverse directions. Residual eye motion can be compensated through postprocessing. Cross sectional and en face images with arbitrary orientation can be extracted from the resulting data sets to investigate structure and pathology. Time dependent measurements can be performed by repeatedly acquiring volumetric data.

Conclusions: : New spectral and swept source / Fourier domain OCT technologies enable ultrahigh speed ophthalmic OCT imaging with speeds almost an order of magnitude faster than what is typical in current commercial instruments. The prototype OCT instruments are characterized in the lab and demonstrated in the clinic for the first time to show a variety of retinal pathologies. The resulting 3D-OCT data sets provide comprehensive and high resolution visualization of the retina, which promises to improve disease detection and treatment monitoring.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina • image processing 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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