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O. Puzyeyeva, S. Duench, T. Simpson, C. Hudson; Conjunctival Blood Oxygen Saturation in Healthy Individuals. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1029.
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© ARVO (1962-2015); The Authors (2016-present)
To quantify the within session variability and between-session repeatability of conjunctival blood oxygen saturation measurements.
To measure conjunctival blood oxygen saturation, images of temporal conjunctival vessels at 440 nm (O2 sensitive) and at 570 nm (O2 insensitive) were acquired. The within session variability and between session repeatability of blood oxygen saturation, the coefficient of variability (COV) and coefficient of repeatability (COR) were estimated. The calculated blood oxygen saturation values were compared between small and large diameter conjunctival vessels in the same individuals. The parameters of oxygen saturation and age of the participants were correlated.
The sample comprised 13 healthy individuals (5 males, 8 females mean age 39.38, SD 13.02, age range 24-59 years). The estimation of COV and COR was performed in 5 subjects. The group mean COV of oxygen saturation was 4.3 % and individual values varied from 3.2 - 5.2% (relative to a mean of 87.2%). The group mean COR was 8.9% and individual values varied between 4.2-12.5 % relative to a mean effect of 87.2%. The comparison of oxygen saturation between small and large conjunctival vessels showed significantly reduced values in large vessels within an individual (paired t-test, p=0.005). The blood oxygen saturation decreased with increasing age (Pearson correlation, r = - 0.58, p=0.037).
This study quantified a variability and repeatability of conjunctival blood oxygen saturation measurements. The influence of vessel diameter on oxygen saturation will be discussed. Further validation studies are needed to evaluate this technique in patients with vascular diseases.
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