Purchase this article with an account.
J. Wang, E. Hatef Naimi, R. Channa, M. Ibrahim, P. Turkcuoglu, Z. Rentiya, A. Khwaja, D. V. Do, Q. D. Nguyen; Fixation Pattern and Macular Sensitivity in Eyes With Uveitic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1039.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Persistent macular edema often leads to visual loss in uveitis and ocular inflammatory diseases. We investigate the effects of uveitic macular edema (UME) on macular functional parameters quantified with an automatic microperimetry and correlated with retinal thickness.
20 eyes of 14 patients with UME were evaluated with spectral optical coherence tomography / scanning laser ophthalmoscope (Spectral OCT/SLOTM, OPKO/OTI, Toronto, Canada) by the same operator. Spectral OCT was used to characterize the type of macular edema. Microperimetry together with retinal thickness map were used to quantify fixation pattern (location and stability), macular sensitivity, and corresponding retinal thickness at 28 test points. Multiple linear regression model with generalized estimation equation was used to evaluate relationship between macular sensitivity and thickness, duration, and type of UME.
Of 14 patients, the mean age was 52.8±18.8 years, range 23-86 years. Associated uveitic diseases include: intermediate uveitis (8 eyes), idiopathic posterior uveitis (5), sarcoidosis-associated panuveitis (2), multifocal choroiditis (2), birdshot chorioretinopathy (2), and Lyme disease-associated posterior uveitis (1). The mean duration of UME was 8.1±4.2 months, range 3-18 months. Spectral OCT revealed 7 eyes (35%) with cystoid macular edema (CME) and 13 eyes (65%) with diffuse macular edema. Fixation pattern revealed that 17 eyes (85%) with central (more than 50% of fixation points within 0.5mm from fovea center); 2 eyes (10%) pericentral ( 25% - 50% within 0.5mm ); and 1 eye (5%) eccentric (less than 25% within 0.5mm ). All 3 eyes with eccentric or pericentral fixation had CME. Fixation stability revealed that 18 eyes (90%) had stable fixation (more than 75% of fixation points within central 2° area); 2 eyes (10%) relatively unstable fixation (less than 75% within 2°, but more than 75% within central 4° area); no eye had unstable fixation (less than 75% of fixation points within central 4°area). Both eyes with relatively unstable fixation had CME. The macular sensitivity was significantly related to the duration of UME (P=0.0001), but not to the retinal thickness (P=0.141) or the type of UME (P=0.659).
Microperimetry quantification of macular sensitivity and fixation patterns may offer novel information regarding the impact of visual impairment on eyes with UME. Further and larger systematic evaluations are indicated to enhance the functional assessment of UME.
This PDF is available to Subscribers Only