April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Fixation Pattern and Macular Sensitivity in Eyes With Uveitic Macular Edema
J. Wang; E. Hatef Naimi; R. Channa; M. Ibrahim; P. Turkcuoglu; Z. Rentiya; A. Khwaja; D. V. Do; Q. D. Nguyen
Author Affiliations & Notes
  • J. Wang
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland
  • E. Hatef Naimi
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland
  • R. Channa
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland
  • M. Ibrahim
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland
  • P. Turkcuoglu
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland
  • Z. Rentiya
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland
  • A. Khwaja
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland
  • D. V. Do
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland
  • Q. D. Nguyen
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  J. Wang, None; E. Hatef Naimi, None; R. Channa, None; M. Ibrahim, None; P. Turkcuoglu, None; Z. Rentiya, None; A. Khwaja, None; D.V. Do, None; Q.D. Nguyen, OPKO/OTI (research funding), F.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1039. doi:
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      J. Wang, E. Hatef Naimi, R. Channa, M. Ibrahim, P. Turkcuoglu, Z. Rentiya, A. Khwaja, D. V. Do, Q. D. Nguyen; Fixation Pattern and Macular Sensitivity in Eyes With Uveitic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1039.

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Abstract

Purpose: : Persistent macular edema often leads to visual loss in uveitis and ocular inflammatory diseases. We investigate the effects of uveitic macular edema (UME) on macular functional parameters quantified with an automatic microperimetry and correlated with retinal thickness.

Methods: : 20 eyes of 14 patients with UME were evaluated with spectral optical coherence tomography / scanning laser ophthalmoscope (Spectral OCT/SLOTM, OPKO/OTI, Toronto, Canada) by the same operator. Spectral OCT was used to characterize the type of macular edema. Microperimetry together with retinal thickness map were used to quantify fixation pattern (location and stability), macular sensitivity, and corresponding retinal thickness at 28 test points. Multiple linear regression model with generalized estimation equation was used to evaluate relationship between macular sensitivity and thickness, duration, and type of UME.

Results: : Of 14 patients, the mean age was 52.8±18.8 years, range 23-86 years. Associated uveitic diseases include: intermediate uveitis (8 eyes), idiopathic posterior uveitis (5), sarcoidosis-associated panuveitis (2), multifocal choroiditis (2), birdshot chorioretinopathy (2), and Lyme disease-associated posterior uveitis (1). The mean duration of UME was 8.1±4.2 months, range 3-18 months. Spectral OCT revealed 7 eyes (35%) with cystoid macular edema (CME) and 13 eyes (65%) with diffuse macular edema. Fixation pattern revealed that 17 eyes (85%) with central (more than 50% of fixation points within 0.5mm from fovea center); 2 eyes (10%) pericentral ( 25% - 50% within 0.5mm ); and 1 eye (5%) eccentric (less than 25% within 0.5mm ). All 3 eyes with eccentric or pericentral fixation had CME. Fixation stability revealed that 18 eyes (90%) had stable fixation (more than 75% of fixation points within central 2° area); 2 eyes (10%) relatively unstable fixation (less than 75% within 2°, but more than 75% within central 4° area); no eye had unstable fixation (less than 75% of fixation points within central 4°area). Both eyes with relatively unstable fixation had CME. The macular sensitivity was significantly related to the duration of UME (P=0.0001), but not to the retinal thickness (P=0.141) or the type of UME (P=0.659).

Conclusions: : Microperimetry quantification of macular sensitivity and fixation patterns may offer novel information regarding the impact of visual impairment on eyes with UME. Further and larger systematic evaluations are indicated to enhance the functional assessment of UME.

Keywords: imaging/image analysis: clinical • macula/fovea • uvea 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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