April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Structure-Function Correlation of the Human Central Retina
Author Affiliations & Notes
  • P. Charbel Issa
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • E. Troeger
    Biomedical Engineering Lab, Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany
  • R. P. Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • F. G. Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • R. Wilke
    Biomedical Engineering Lab, Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
  • H. P. N. Scholl
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  P. Charbel Issa, Heidelberg Engineering, R; E. Troeger, None; R.P. Finger, None; F.G. Holz, Heidelberg Engineering, C; Heidelberg Engineering, R; R. Wilke, None; H.P.N. Scholl, None.
  • Footnotes
    Support  European Commission, FP6, Integrated Project "EVI-GENORET" (LSHG-CT-2005-512036), EU FP7 Marie Curie Intra-European Fellowship 237238; Lowy Medical Research Institute
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1040. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P. Charbel Issa, E. Troeger, R. P. Finger, F. G. Holz, R. Wilke, H. P. N. Scholl; Structure-Function Correlation of the Human Central Retina. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1040.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To precisely correlate high resolution structural and functional maps of the human macula.

Methods: : A custom-made software tool (MultiModalMapper) allowed for co-registration of fundus-mapped microperimetry (MP1, Nidek) and spectral domain optical coherence tomography (SD-OCT; Spectralis HRA+OCT, Heidelberg Engineering) datasets. The transformation model features mapping of 2D microperimetry data on 3D-OCT datasets using corresponding landmarks on both fundus images. The software accounts for different radial lens distortion of both systems. Well-defined features of structure-function correlation are exemplified in macular telangiectasia (MacTel) type 2. Longitudinal data were analyzed from the RAMA-trial (ranibizumab for MacTel type 2; ClinicalTrials identifier: NCT00504400). The study received ethical approval by the local committee and each patient gave written informed consent to participate.

Results: : While damage to the outer retina (photoreceptors) was accompanied by a loss of retinal sensitivity as measured by microperimetry, similar changes to the inner retina usually showed a normal corresponding function. There was a significant correlation between thickness of outer retina and retinal sensitivity (r=0.8; p<0.001, two-tailed Pearson correlation coefficient). Longitudinal data from the RAMA-trial revealed that small lesions affecting the outermost neurosensory retina typically precede functional detection but later cause severe loss of light sensitivity.

Conclusions: : There can be remarkable functional compensation if the macular pathology spares the outer neurosensory retina. There is a general need for surrogate endpoints to diagnose disease in its early stages, when treatment is most effective and irreversible (functional) damage can be prevented or delayed. Since SD-OCT is becoming more widely available, surrogate endpoints derived from structure-function correlation may become highly relevant in future clinical trials.

Clinical Trial: : www.clinicaltrials.gov NCT00504400

Keywords: macula/fovea • imaging/image analysis: clinical • perimetry 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×