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A. D. Kulkarni, A. Domalpally, Q. Peng, R. P. Danis; Correlation of Visual Acuity to Outer Retinal Morphology in Spectral Domain OCT Images of Retinal Diseases. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1041.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the relationship between visual acuity (VA) and outer retinal morphology evaluated from spectral domain optical coherence tomography (SDOCT) images in various retinal diseases.
A series of 73 patients (136 eyes) requiring SDOCT for standard of care assessment of retinal disease were recruited for this study. All subjects were scanned using the Topcon 3D OCT-1000 with the cube scan protocol (6 x 6 mm area; 128 B-scans;512 A scans / B scan) The evaluation was limited to the 20 B scans passing through the central subfield (CSF). It included integrity of the external limiting membrane (ELM) and photoreceptor inner segment-outer segment (IS-OS) junction. Every scan was evaluated by two examiners. Using a 3 step scale the ELM and the IS-OS junction in the CSF were graded as absent, abnormal and normal. VA was measured on a Snellen chart with the patient’s habitual refraction and converted to logarithm of minimal angle of resolution (logMAR) units for statistical analysis.
All scans obtained were of gradable quality for outer retinal integrity. The percentage agreement and kappa statistics was 69 % (0.53) for grading of the ELM, and 72 % (0.54) for IS-OS. The mean logMAR VA was 0.8 (n=39) for eyes with absent ELM, 0.3 (n=33) for abnormal ELM and 0.2 (n=61) for normal ELM (p value<0.001). For IS-OS status, the mean logMAR VA was 0.9 (n=30) for absent IS-OS, 0.4 (n=38) for abnormal IS-OS and 0.2 (n=65) for normal IS-OS (p value <0.001). The trend in distribution of VA along the 3 step scale of ELM and IS-OS remained in most disease categories although the numbers were small.
A statistically significant association between ELM, IS-OS integrity and VA suggests that outer retinal morphology evaluation by SDOCT may provide useful variables for clinical research and care.
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