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T. Ristau, P. A. Keane, J. Updike, A. C. Walsh, A. Engin, S. Hillebrand, B. Kirchhof, S. R. Sadda, S. Liakopoulos; Relationship Between Spectral Domain Optical Coherence Tomography Retinal Parameters and Visual Acuity in Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1045.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the relationship between pre-treatment spectral domain optical coherence tomography (SDOCT) - derived measurements of retinal morphology and visual acuity in patients with neovascular age-related macular degeneration (AMD).
Best-corrected visual acuity of 40 previously untreated eyes with active neovascular AMD were retrospectively collected. Spectralis SDOCT volume scans were analyzed for all cases using custom software (termed 3D OCTOR). This software allows the user to manually define the borders of various retinal and subretinal spaces on each OCT B-scan and to calculate thickness and volume measurements. Delineated spaces included the neurosensory retina, the outer nuclear layer, subretinal fluid, subretinal tissue, and pigment epithelial detachments (PED). For each OCT set, the foveal center was manually defined and the volume of the foveal central subfield as well as the central foveal thickness was calculated for all spaces and correlated with visual acuity (Pearson correlation).
Poorer visual acuity showed a statistically significant correlation with an increased central volume of the retina (p=0.04, R=0.33), increased volume of a PED (p=0.03, R=0.34) and increased volume of subretinal tissue (p=0.009, R=0.41), as well as with a decreased volume of the outer nuclear layer (p=0.016, R=0.38). The volume of subretinal fluid did not show a significant correlation with visual acuity. Central foveal thickness measurements revealed significant correlations for retinal thickness (p=0.03, R=0.35), thickness of subretinal tissue (p=0.006, R=0.43) and thickness of the outer nuclear layer (p=0.02, R=-0.37), but not for thickness of PED and subretinal fluid.
Quantitative analysis of high resolution SDOCT volume scans using the manual grading software 3D OCTOR revealed significant correlations between visual acuity and various retinal and subretinal morphological changes in patients with previously untreated neovascular AMD. Quantitative OCT analysis of a larger dataset may allow for even stronger correlations and improve our understanding of the impact of neovascular AMD on retinal function.
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