April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Relationship Between Spectral Domain Optical Coherence Tomography Retinal Parameters and Visual Acuity in Neovascular Age-Related Macular Degeneration
T. Ristau; P. A. Keane; J. Updike; A. C. Walsh; A. Engin; S. Hillebrand; B. Kirchhof; S. R. Sadda; S. Liakopoulos
Author Affiliations & Notes
  • T. Ristau
    Center for Ophthalmology, University of Cologne, Cologne, Germany
  • P. A. Keane
    Doheny Eye Institute, Los Angeles, California
  • J. Updike
    Doheny Eye Institute, Los Angeles, California
  • A. C. Walsh
    Doheny Eye Institute, Los Angeles, California
  • A. Engin
    Center for Ophthalmology, University of Cologne, Cologne, Germany
  • S. Hillebrand
    Center for Ophthalmology, University of Cologne, Cologne, Germany
  • B. Kirchhof
    Center for Ophthalmology, University of Cologne, Cologne, Germany
  • S. R. Sadda
    Doheny Eye Institute, Los Angeles, California
  • S. Liakopoulos
    Center for Ophthalmology, University of Cologne, Cologne, Germany
  • Footnotes
    Commercial Relationships  T. Ristau, None; P.A. Keane, None; J. Updike, Topcon, P; A.C. Walsh, Topcon, P; Heidelberg Engineering, C; Topcon, R; A. Engin, None; S. Hillebrand, None; B. Kirchhof, None; S.R. Sadda, Carl Zeiss Meditec, F; Optovue, Inc., F; Heidelberg Engineering, C; Topcon Medical Systems, P; Topcon Medical Systems, R; S. Liakopoulos, Heidelberg Engineering, R.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1045. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Relationship Between Spectral Domain Optical Coherence Tomography Retinal Parameters and Visual Acuity in Neovascular Age-Related Macular Degeneration
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      T. Ristau, P. A. Keane, J. Updike, A. C. Walsh, A. Engin, S. Hillebrand, B. Kirchhof, S. R. Sadda, S. Liakopoulos; Relationship Between Spectral Domain Optical Coherence Tomography Retinal Parameters and Visual Acuity in Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1045.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : To investigate the relationship between pre-treatment spectral domain optical coherence tomography (SDOCT) - derived measurements of retinal morphology and visual acuity in patients with neovascular age-related macular degeneration (AMD).

Methods: : Best-corrected visual acuity of 40 previously untreated eyes with active neovascular AMD were retrospectively collected. Spectralis SDOCT volume scans were analyzed for all cases using custom software (termed 3D OCTOR). This software allows the user to manually define the borders of various retinal and subretinal spaces on each OCT B-scan and to calculate thickness and volume measurements. Delineated spaces included the neurosensory retina, the outer nuclear layer, subretinal fluid, subretinal tissue, and pigment epithelial detachments (PED). For each OCT set, the foveal center was manually defined and the volume of the foveal central subfield as well as the central foveal thickness was calculated for all spaces and correlated with visual acuity (Pearson correlation).

Results: : Poorer visual acuity showed a statistically significant correlation with an increased central volume of the retina (p=0.04, R=0.33), increased volume of a PED (p=0.03, R=0.34) and increased volume of subretinal tissue (p=0.009, R=0.41), as well as with a decreased volume of the outer nuclear layer (p=0.016, R=0.38). The volume of subretinal fluid did not show a significant correlation with visual acuity. Central foveal thickness measurements revealed significant correlations for retinal thickness (p=0.03, R=0.35), thickness of subretinal tissue (p=0.006, R=0.43) and thickness of the outer nuclear layer (p=0.02, R=-0.37), but not for thickness of PED and subretinal fluid.

Conclusions: : Quantitative analysis of high resolution SDOCT volume scans using the manual grading software 3D OCTOR revealed significant correlations between visual acuity and various retinal and subretinal morphological changes in patients with previously untreated neovascular AMD. Quantitative OCT analysis of a larger dataset may allow for even stronger correlations and improve our understanding of the impact of neovascular AMD on retinal function.

Keywords: age-related macular degeneration • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • visual acuity 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept