April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Increased Foveal Avascular Zone in Diabetic Retinopathy Patients Detected Non-Invasively by the Retinal Function Imager
Author Affiliations & Notes
  • D. A. Nelson
    Optical Imaging Ltd, Rehovot, Israel
  • H. Barash
    Optical Imaging Ltd, Rehovot, Israel
  • A. Ruf
    Optical Imaging Ltd, Rehovot, Israel
  • Z. Burgansky-Eliash
    Department of Ophthalmology, The Edith Wolfson Medical Center, Holon, Israel
  • D. Izhaky
    Optical Imaging Ltd, Rehovot, Israel
  • A. Barak
    Department of Ophthalmology, Sourasky Medical Center, Tel-Aviv, Israel
  • A. Lowenstein
    Department of Ophthalmology, Sourasky Medical Center, Tel-Aviv, Israel
  • T. Rock
    Department of Ophthalmology, The Edith Wolfson Medical Center, Holon, Israel
  • E. Bartov
    Department of Ophthalmology, The Edith Wolfson Medical Center, Holon, Israel
  • A. Grinvald
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
  • Footnotes
    Commercial Relationships  D.A. Nelson, Optical Imaging Ltd, E; H. Barash, Optical Imaging Ltd, E; A. Ruf, Optical Imaging Ltd, E; Z. Burgansky-Eliash, Optical Imaging Ltd, E; D. Izhaky, Optical Imaging Ltd, E; A. Barak, None; A. Lowenstein, None; T. Rock, None; E. Bartov, None; A. Grinvald, Optical Imaging Ltd, I; Optical Imaging Ltd, P.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1056. doi:https://doi.org/
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      D. A. Nelson, H. Barash, A. Ruf, Z. Burgansky-Eliash, D. Izhaky, A. Barak, A. Lowenstein, T. Rock, E. Bartov, A. Grinvald; Increased Foveal Avascular Zone in Diabetic Retinopathy Patients Detected Non-Invasively by the Retinal Function Imager. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1056. doi: https://doi.org/.

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Abstract
 
Purpose:
 

To non-invasively measure and compare the foveal avascular zone (FAZ) in healthy subjects and diabetic retinopathy (DR) patients. We used the Retinal Function Imager (RFI, Optical Imaging, Ltd) to image the retinal vascular network.

 
Methods:
 

Fourteen eyes of 11 DR patients and 22 eyes of 18 healthy subjects were recruited. Multiple RFI retinal image series (each made of 8 images, 55 Hz) were acquired from each subject. Following registration, pixel values were analyzed to locate blood motion, thus obtaining non-invasive capillary perfusion maps (nCPM) at high resolution. FAZ dimensions were measured using ImageJ 1.42q (NIH, USA). Comparison between groups was done using student t-test.

 
Results:
 

The average FAZ area in patients with DR was significantly larger compared to controls (0.21±0.07 vs 0.13±0.06 mm2, p<0.001), as was the FAZ diameter (657±72 vs 480±95 µm, p<0.001) (Fig. 1).

 
Conclusions:
 

Using the RFI we detected a significantly enlarged FAZ area in patients with DR, which represents the ischemic process in the diabetic eye. Non-invasive and safe monitoring of the FAZ dimensions may provide an important tool for early diagnosis, follow-up and tailoring treatment in diabetic patients.Fig. 1 nCPMs of (A) a Healthy subject; (B) a DR (diabetic retinopathy) patient. Area and diameter of FAZ: (A) 0.114mm2, 464µm; (B) 0.225 mm2, 672µm. The green line encircles the FAZ.  

 
Keywords: imaging/image analysis: clinical • diabetic retinopathy 
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