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R. Roberts, D. Bissig, D. Bergman, V. K. Kasturi, W. W. Tschetter, G. Prusky, B. Berkowitz; Evidence for a Link Between Outer Retinal Ion Regulation and Optokinetic Spatial Frequency Threshold. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1062.
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© ARVO (1962-2015); The Authors (2016-present)
To test the hypothesis of a link between changes in outer retinal ion regulation measured with manganese-enhanced MRI (MEMRI) and changes in an optokinetic tracking (OKT) metric of visual performance, the spatial frequency threshold.
Two validation experiments were performed comparing retinal uptake of manganese and OKT spatial frequency threshold: in rodents between postnatal day 12 (P12) and P48, and in adult rodents before, during, and after treatment with diltiazem. In addition, the effect of disease on this link was assessed in diabetic and age-matched control rodents.
Retinal manganese uptake and OKT developmental growth curves had slopes with overlapping 95% confidence limits. Comparable dose and temporal evolution patterns following diltiazem treatment were noted between retinal manganese uptake and OKT threshold data. Decreased OKT threshold corresponded to diabetes-induced reductions in retinal manganese uptake.
These results raise the possibility of a link between outer retinal ion regulation and an OKT measure of visual performance in normal and diabetic rodents.
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