April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Evidence for a Link Between Outer Retinal Ion Regulation and Optokinetic Spatial Frequency Threshold
R. Roberts; D. Bissig; D. Bergman; V. K. Kasturi; W. W. Tschetter; G. Prusky; B. Berkowitz
Author Affiliations & Notes
  • R. Roberts
    Anatomy & Cell Biol, Wayne State Univ Sch of Med, Detroit, Michigan
  • D. Bissig
    Anatomy & Cell Biol, Wayne State Univ Sch of Med, Detroit, Michigan
  • D. Bergman
    Anatomy & Cell Biol, Wayne State Univ Sch of Med, Detroit, Michigan
  • V. K. Kasturi
    Anatomy & Cell Biol, Wayne State Univ Sch of Med, Detroit, Michigan
  • W. W. Tschetter
    Physiology and Biophysics, Weill Cornell Medical College, Burke Medical Research Institute, White Plains, New York
  • G. Prusky
    Physiology and Biophysics, Weill Cornell Medical College, Burke Medical Research Institute, White Plains, New York
  • B. Berkowitz
    Anatomy & Cell Biol, Wayne State Univ Sch of Med, Detroit, Michigan
    Ophthalmology, Wayne State University, Detroit, Michigan
  • Footnotes
    Commercial Relationships  R. Roberts, None; D. Bissig, None; D. Bergman, None; V.K. Kasturi, None; W.W. Tschetter, None; G. Prusky, None; B. Berkowitz, None.
  • Footnotes
    Support  NIH EY010221 (BAB); JDRF (BAB); NIH AMDCC/MMPC (BAB); and RPB (Kresge Eye Institute)
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1062. doi:
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      R. Roberts, D. Bissig, D. Bergman, V. K. Kasturi, W. W. Tschetter, G. Prusky, B. Berkowitz; Evidence for a Link Between Outer Retinal Ion Regulation and Optokinetic Spatial Frequency Threshold. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1062.

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Abstract

Purpose: : To test the hypothesis of a link between changes in outer retinal ion regulation measured with manganese-enhanced MRI (MEMRI) and changes in an optokinetic tracking (OKT) metric of visual performance, the spatial frequency threshold.

Methods: : Two validation experiments were performed comparing retinal uptake of manganese and OKT spatial frequency threshold: in rodents between postnatal day 12 (P12) and P48, and in adult rodents before, during, and after treatment with diltiazem. In addition, the effect of disease on this link was assessed in diabetic and age-matched control rodents.

Results: : Retinal manganese uptake and OKT developmental growth curves had slopes with overlapping 95% confidence limits. Comparable dose and temporal evolution patterns following diltiazem treatment were noted between retinal manganese uptake and OKT threshold data. Decreased OKT threshold corresponded to diabetes-induced reductions in retinal manganese uptake.

Conclusions: : These results raise the possibility of a link between outer retinal ion regulation and an OKT measure of visual performance in normal and diabetic rodents.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • visual acuity • diabetic retinopathy 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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