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G.-H. Peng, A. K. Hennig, Y. Chen, S. Chen; Histone Acetyltransferases CBP and p300 in Photoreceptors: Loss-of-Function Affects Chromatin Configuration and Transcription of Photoreceptor Genes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1086.
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The histone acetyltransferases (HATs) CBP and p300 are co-activators of the cone-rod homeobox protein CRX. Their recruitment by CRX to target gene promoters correlates with enhanced histone acetylation and transcription activation. This study was designed to determine the role of CBP and p300 in CRX-regulated chromatin remodeling and target gene transcription in rod photoreceptors.
Ongoing expression of CBP and p300 is essential for maintaining expression of CRX target genes by keeping appropriate levels of acetylated histone H3 on target gene promoters. Appropriate photoreceptor gene expression requires the coordinated action of both photoreceptor-specific transcription factors and general chromatin modulators.
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