April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Histone Acetyltransferases CBP and p300 in Photoreceptors: Loss-of-Function Affects Chromatin Configuration and Transcription of Photoreceptor Genes
Author Affiliations & Notes
  • G.-H. Peng
    Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
  • A. K. Hennig
    Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
  • Y. Chen
    Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
  • S. Chen
    Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
  • Footnotes
    Commercial Relationships  G.-H. Peng, None; A.K. Hennig, None; Y. Chen, None; S. Chen, None.
  • Footnotes
    Support  Grants from NIH R01 EY012543-10 (to SC) and P30 EY02687 (to WU-DOVS), Research to Prevent Blindness (to SC and WU-DOVS).
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1086. doi:
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    • Get Citation

      G.-H. Peng, A. K. Hennig, Y. Chen, S. Chen; Histone Acetyltransferases CBP and p300 in Photoreceptors: Loss-of-Function Affects Chromatin Configuration and Transcription of Photoreceptor Genes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1086.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : The histone acetyltransferases (HATs) CBP and p300 are co-activators of the cone-rod homeobox protein CRX. Their recruitment by CRX to target gene promoters correlates with enhanced histone acetylation and transcription activation. This study was designed to determine the role of CBP and p300 in CRX-regulated chromatin remodeling and target gene transcription in rod photoreceptors.

Methods: : Cbp

Results: : Cbp/p300

Conclusions: : Ongoing expression of CBP and p300 is essential for maintaining expression of CRX target genes by keeping appropriate levels of acetylated histone H3 on target gene promoters. Appropriate photoreceptor gene expression requires the coordinated action of both photoreceptor-specific transcription factors and general chromatin modulators.

Keywords: transcription factors • photoreceptors • gene/expression 
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