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S. Ishibashi, A. Tawara, R. Sohma, T. Kubota, N. Toh; Effects of Intravitreal Bevacizumab on Anterior Segment Neovascularization in Neovascular Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):634.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effects of the intravitreal injection of bevacizumab (IVB) on the anterior segment neovascularization in neovascular glaucoma (NVG) by anterior segment angiography.
This study observed two eyes from 2 normal volunteers and 4 with NVG from 4 patients suffering from diabetic retinopathy in 3 and central retinal vein occlusion in one. Three eyes, including 1 normal eye, had iris angiography and the others underwent iridocorneal angle angiography with both fluorescein (FA) and indocyanine green angiography (IA) using a Heidelberg retina angiograph 2. After the angiography, 4 eyes with NVG were treated with IVB (1.25mg/0.05ml), and then underwent angiography again from 4 to 6 days after the treatment.
Iris angiography showed many iris vessels without leaking with IA, and intensive leakage from the vessels in NVG but not in normal with FA. Angle angiography revealed vessel structures with IA and intensive leakage with FA in NVG, while no vessel structures appeared with either IA or FA in the normal eye. After the IVB in the eyes with NVG, the vascular structure did not change with IA, but dye leakage remarkably decreased with FA in both the iris and angle, although the newly formed vessels in the iris and iridocorneal angle seemed to vanish based on slit-lamp examinations.
The IVB effectively reduces vascular permeability, whereas the newly formed vessels are still present in the iris and iridocorneal angle.
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