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L. P. Cunha, L. V. F. Costa-Cunha, M. L. R. Monteiro; Correlation Between Optical Coherence Tomography and Multifocal Pattern Electroretinogram in Eyes With Temporal Hemianopia From Chiasmal Compression. Invest. Ophthalmol. Vis. Sci. 2010;51(13):651.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the correlation between multifocal pattern electroretinogram (mfPERG) amplitude and optical coherence tomography (OCT) macular thickness in eyes with temporal hemianopia from chiasmal compression.
Twenty-two eyes from 22 patients with permanent temporal VF defects from chiasmal compression and 12 eyes from 12 healthy subjects underwent mfPERG using a stimulus pattern of 19 rectangles, each consisting of twelve squares, standard automated perimetry (SAP) and fourier domain-OCT macular and RNFL thickness measurements. The response was averaged for a subset of 8 nasal rectangles and for a subset of 8 temporal rectangles in both patients and controls. Comparisons were made using Student’s t test. Deviation from normal VF sensitivity for the central 18° of VF was expressed in 1/Lambert units. Correlations between measurements were verified with Spearman’s rank correlation coefficients.
Temporal mfPERG and nasal OCT macular measurements were significantly lower in eyes with temporal hemianopia than in normals. A significant correlation was found between Visual Field (VF) sensitivity loss and temporal hemifield mfPERG amplitude. Likewise a significant correlation was found between VF sensitivity loss and most OCT macular parameters. A significant correlation was also observed between nasal OCT macular and temporal mfPERG parameters.
In patients with chiasmal compression, mfPERG amplitude and OCT thickness measurements were significant related to VF loss, and to each other. Both OCT and mfPERG quantify neuronal loss and both technologies are useful in understanding structure-function relationship in patients with chiasmal compression.
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