April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
The Use of Human Fibrin Tissue Adhesive as an Alternative Method to Sutures in Deep Anterior Lamellar Keratoplasty: An Anatomical Evaluation
Author Affiliations & Notes
  • N. Wongpitoonpiya
    Ophthalmology, Shiley Eye Center, San Diego, California
  • K. Bottos
    Ophthalmology, Shiley Eye Center, San Diego, California
  • T. Purcell
    Ophthalmology, Shiley Eye Center, San Diego, California
  • M. Isidro
    Ophthalmology, Shiley Eye Center, San Diego, California
  • D. Schanzlin
    Ophthalmology, Shiley Eye Center, San Diego, California
  • Footnotes
    Commercial Relationships  N. Wongpitoonpiya, None; K. Bottos, None; T. Purcell, None; M. Isidro, None; D. Schanzlin, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 735. doi:
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    • Get Citation

      N. Wongpitoonpiya, K. Bottos, T. Purcell, M. Isidro, D. Schanzlin; The Use of Human Fibrin Tissue Adhesive as an Alternative Method to Sutures in Deep Anterior Lamellar Keratoplasty: An Anatomical Evaluation. Invest. Ophthalmol. Vis. Sci. 2010;51(13):735.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To demonstrate the results of using fibrin glue adhesive vs conventional sutures in Deep Anterior Lamellar Keratoplasty

 
Methods:
 

Ten human eye globes and 10 donor corneas were obtained from San Diego Eye Bank. Deep anterior lamellar dissection was performed on all globes using the Anwar Big Bubble Technique. Microkeratome cut lamellar buttons were then placed on the recipient residual stromal bed. In five of the eyes, we used the traditional method of placing 16 sutures to secure the button; in the other five eyes we used fibrin glue to oppose the wound edge. We then took high resolution images of the wound edges and interface with the Anterior Segment OCT .

 
Results:
 

Evaluation by the Anterior Segment OCT demonstrated that the corneal wound edges in DALK which were applied with fibrin glue showed a smooth and regular surface comparable to the traditional 16-suture method. The fibrin glue method also resulted in reduced operation time.

 
Conclusions:
 

Fibrin glue may be used as a modified technique to attach the corneal button in DALK without the use of sutures. This technique is fast, easy and may prevent potential complications caused by sutures. Moreover, fibrin glue use may result in less induced astigmatism. Future experiments utilizing this technique with the femtosecond laser-assisted cut may show even better results by providing more precise approximation of the wound edge.  

 
Keywords: transplantation • cornea: clinical science • anterior segment 
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