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M. Taneja, D. Nankivil, A. Mohamed, V. Pesala, X. Hao, T. Hughes, Q. Garrett, K. Ehrmann, F. Manns, A. Ho; Optomechanical Response of Human Lenses Refilled With Polymer Gel. Invest. Ophthalmol. Vis. Sci. 2010;51(13):808.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the optomechanical response of the human lenses before and after lens refilling.
Thirteen post-mortem (40.4±17.1 hours) eyes from eight human donors (30.1±12.8 y/o, range 14-50 y/o) were dissected leaving intact the lens, zonules, ciliary body, hyaloid membrane, anterior vitreous and a segmented scleral rim. The lens preparation was mounted in a lens stretching system and the sclera was stretched 2 mm radially in a step-wise fashion (0.25 mm/step). The load and the lens and ciliary body diameter and lens power were measured at each step. The lens contents were removed and the capsular bag was filled with a flexible polymer gel. The changes in the lens and ciliary body diameter and the lens power, and load relationships were compared before and after refilling.
The lens diameter, ciliary body diameter, power, and the changes in lens diameter and power all increased after lens refilling, from 9.01±0.41 mm to 9.05±0.48 mm (p = 0.030), 11.38±0.61 mm to 11.51±0.95 mm (p = 0.033), 21.79±2.72 D to 25.79±3.49 D (p = 0.017), 0.27±0.08 mm to 0.42±0.05 mm (p < 0.001) and 2.51±1.81 D to 4.78±2.07 D (p = 0.008) respectively. The maximum stretching force decreased after lens refilling from 8.93±1.17 g to 7.80±0.70 g (p = 0.006).
Lens refilling can produce a significant increase in the change in lens diameter and optical power in human lenses.Acknowledgement: Scientific support from Drs. Pravin K Vaddavalli1, Virender Sangwan1 and Jean-Marie Parel2,3,6
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