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I. Belinsky, C. Shields, J. Markowitz, H. Schwartzstein, N. George, S. Lally, A. Mashayekhi, J. Shields; Conjunctival Melanoma: Origin From Primary Acquired Melanosis and Nevus Shows Less Risk for Melanoma-Related Death Than Origin de Novo. Invest. Ophthalmol. Vis. Sci. 2010;51(13):849.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate death from conjunctival melanoma.
Retrospective review of 382 cases.
The mean patient age at presentation was 59 years (range: 10-92 years). The melanoma arose from primary acquired melanosis (PAM) (74%), nevus (7%), or de novo (19%). At 5 and 10 years, melanoma-related death occurred in 9% from PAM (p<0.001), 9% from nevus (p<0.057), and 35% from de novo. At 5 and 10 years, melanoma metastasis occurred in 19% and 25% from PAM (p=0.003), 10% and 26% from nevus (p=0.193), and 35% and 49% from de novo. Risks for metastasis included de novo origin, palpebral location, nodular appearance, and orbital invasion.
Conjunctival melanoma from de novo origin imparts worse prognosis than those of PAM or nevus origin.
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