April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Conjunctival Melanoma: Origin From Primary Acquired Melanosis and Nevus Shows Less Risk for Melanoma-Related Death Than Origin de Novo
I. Belinsky; C. Shields; J. Markowitz; H. Schwartzstein; N. George; S. Lally; A. Mashayekhi; J. Shields
Author Affiliations & Notes
  • I. Belinsky
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • C. Shields
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • J. Markowitz
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • H. Schwartzstein
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • N. George
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • S. Lally
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • A. Mashayekhi
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • J. Shields
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  I. Belinsky, None; C. Shields, None; J. Markowitz, None; H. Schwartzstein, None; N. George, None; S. Lally, None; A. Mashayekhi, None; J. Shields, None.
  • Footnotes
    Support  Donation from Michael, Bruce, and Ellen Ratner, New York, NY; Mellon Charitable Giving from Martha W. Rogers Charitable Trust, Philadelphia, PA; Eye Tumor Research Foundation, Philadelphia, PA
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 849. doi:
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      I. Belinsky, C. Shields, J. Markowitz, H. Schwartzstein, N. George, S. Lally, A. Mashayekhi, J. Shields; Conjunctival Melanoma: Origin From Primary Acquired Melanosis and Nevus Shows Less Risk for Melanoma-Related Death Than Origin de Novo. Invest. Ophthalmol. Vis. Sci. 2010;51(13):849.

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Abstract

Purpose: : To evaluate death from conjunctival melanoma.

Methods: : Retrospective review of 382 cases.

Results: : The mean patient age at presentation was 59 years (range: 10-92 years). The melanoma arose from primary acquired melanosis (PAM) (74%), nevus (7%), or de novo (19%). At 5 and 10 years, melanoma-related death occurred in 9% from PAM (p<0.001), 9% from nevus (p<0.057), and 35% from de novo. At 5 and 10 years, melanoma metastasis occurred in 19% and 25% from PAM (p=0.003), 10% and 26% from nevus (p=0.193), and 35% and 49% from de novo. Risks for metastasis included de novo origin, palpebral location, nodular appearance, and orbital invasion.

Conclusions: : Conjunctival melanoma from de novo origin imparts worse prognosis than those of PAM or nevus origin.

Keywords: oncology • conjunctiva • melanoma 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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