April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Conjunctival Melanoma: Origin From Primary Acquired Melanosis and Nevus Shows Less Risk for Melanoma-Related Death Than Origin de Novo
Author Affiliations & Notes
  • I. Belinsky
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • C. Shields
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • J. Markowitz
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • H. Schwartzstein
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • N. George
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • S. Lally
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • A. Mashayekhi
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
  • J. Shields
    Ophthalmology, Wills Eye Institute, Philadelphia, Pennsylvania
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 849. doi:
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    • Get Citation

      I. Belinsky, C. Shields, J. Markowitz, H. Schwartzstein, N. George, S. Lally, A. Mashayekhi, J. Shields; Conjunctival Melanoma: Origin From Primary Acquired Melanosis and Nevus Shows Less Risk for Melanoma-Related Death Than Origin de Novo. Invest. Ophthalmol. Vis. Sci. 2010;51(13):849.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate death from conjunctival melanoma.

Methods: : Retrospective review of 382 cases.

Results: : The mean patient age at presentation was 59 years (range: 10-92 years). The melanoma arose from primary acquired melanosis (PAM) (74%), nevus (7%), or de novo (19%). At 5 and 10 years, melanoma-related death occurred in 9% from PAM (p<0.001), 9% from nevus (p<0.057), and 35% from de novo. At 5 and 10 years, melanoma metastasis occurred in 19% and 25% from PAM (p=0.003), 10% and 26% from nevus (p=0.193), and 35% and 49% from de novo. Risks for metastasis included de novo origin, palpebral location, nodular appearance, and orbital invasion.

Conclusions: : Conjunctival melanoma from de novo origin imparts worse prognosis than those of PAM or nevus origin.

Keywords: oncology • conjunctiva • melanoma 
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