April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
FDT Matrix in Schizophrenia. Evaluation for Magnocellular Pathway Dysfunction in Schizophrenia and Their Parents
Author Affiliations & Notes
  • C. P. Barbosa
    Ophthalmology, Federal University of São Paulo, Sao Paulo, Brazil
  • F. Benites
    Ophthalmology, Federal University of São Paulo, Sao Paulo, Brazil
  • R. Bressan
    Ophthalmology, Federal University of São Paulo, Sao Paulo, Brazil
  • A. K. Senra
    Ophthalmology, Federal University of São Paulo, Sao Paulo, Brazil
  • L. M. Pinto
    Ophthalmology, Federal University of São Paulo, Sao Paulo, Brazil
  • A. Paranhos, Jr.
    Ophthalmology, Federal University of São Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  C.P. Barbosa, None; F. Benites, None; R. Bressan, None; A.K. Senra, None; L.M. Pinto, None; A. Paranhos, Jr., None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 958. doi:
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      C. P. Barbosa, F. Benites, R. Bressan, A. K. Senra, L. M. Pinto, A. Paranhos, Jr.; FDT Matrix in Schizophrenia. Evaluation for Magnocellular Pathway Dysfunction in Schizophrenia and Their Parents. Invest. Ophthalmol. Vis. Sci. 2010;51(13):958.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the visual pathways deficit in schizophrenia using the frequency doubling technology (FDT- MATRIX) comparing with their relatives and controls.

Methods: : A total of 13 patients and 13 relatives and 19 controls were prospectively enrolled. After a complete ophthalmological examination, those with any ocular disease or previous oculars surgery were excluded. Patients were excluded if they had uncontrolled neurological disorder that might affect their performance. All patients and their parents underwent to FDT- MATRIX perimetry after a careful explanation. The test was performed in one session. The MD (mean-deviation) for each eye was used for analysis. Generalized estimated equation was performed to evaluate differences among the groups and to correct the dependency between the eyes.

Results: : The mean MD (presented as the mean of both eyes but, for calculation, each eye was considered separately) was significantly lower for schizophrenia group (-4.35 dB ± 0.85) in comparison with their parents (-0.23dB ± 0.63) and for the control group (0.74 dB ± 0.33) (p<0.01). There was no significant difference between control group and schizophrenic parents group (p=0.244).

Conclusions: : There is a lower mean MD with FDT MATRIX for schizophrenia parents comparing with control group but the difference did not reached statistical significance. Schizophrenic patients presented a significant lower MD.

Keywords: visual development • imaging/image analysis: clinical • electrophysiology: clinical 
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