April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
R102g Polymorphism of the C3 Gene Associated With Age-Related Macular Degeneration in the French Population
Author Affiliations & Notes
  • N. Puche
    Creteil University Eye Clinic, Paris, France
  • J. Zerbib
    Creteil University Eye Clinic, Paris, France
  • N. Leveziel
    Creteil University Eye Clinic, Paris, France
  • F. Richard
    University Lille Nord of France, INSERM, UMR744, Institut Pasteur of Lille , France, Lille, France
  • S. Cohen
    Ophthalmologic Centre of Imaging and Laser, Paris, France, Paris, France
  • J.-F. Korobelnik
    Ophthalmology, University Pellegrin Hospital, Bordeaux, France, Paris, France
  • J. A. Sahel
    UMR-S 968, Institut de la Vision, Paris, France
  • J. Kaplan
    Hopital des Enfants Malades, INSERM U781, Paris, France
  • J.-M. Rozet
    Genetics U781, INSERM, Paris, France
  • E. Souied
    Creteil University Eye Clinic, Paris, France
  • Footnotes
    Commercial Relationships  N. Puche, None; J. Zerbib, None; N. Leveziel, None; F. Richard, None; S. Cohen, None; J.-F. Korobelnik, None; J.A. Sahel, None; J. Kaplan, None; J.-M. Rozet, None; E. Souied, None.
  • Footnotes
    Support  Fondation pour la Recherche Médicale, Association DMLA
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1271. doi:
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      N. Puche, J. Zerbib, N. Leveziel, F. Richard, S. Cohen, J.-F. Korobelnik, J. A. Sahel, J. Kaplan, J.-M. Rozet, E. Souied; R102g Polymorphism of the C3 Gene Associated With Age-Related Macular Degeneration in the French Population. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1271.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Major genetic factors for age-related macular degeneration (AMD) have recently been identified as susceptibility risk factors, underlying the role of the complement pathway in AMD. Our purpose was to analyze the role of the R102G polymorphism of the C3 gene in a French population, in a case-control study

Methods: : 1241 AMD patients and 406 controls have been recruited in 4 French ophthalmologic centres and genotyped for the Y402H of CFH, rs10490924 of ARMS2 and rs2230199 (R102G) of the C3 gene. Information on cigarette smoking was obtained by interview at baseline.

Results: : The distribution of the R102G genotypes was significantly different in the AMD patients compared to controls (p< 0.02). The adjusted Odds Ratio compared to CC individuals was 1.4 (95% confidence interval 1.1 to 1.8) for CG individuals and 1.5 (95% confidence interval 0.9 to 2.5) for GG individuals. Analysis of the interactions revealed strong interactions between C3 gene and ARMS2, male and smoking.

Conclusions: : Our study show a significant association between R102G variant in the C3 gene and AMD in the French Population, and raise the possibility of interactions between C3 and other risk factors for AMD.

Keywords: age-related macular degeneration • genetics 
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