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J. M. Nolan, M. L. Kirby, J. Stack, M. Harrison, I. Greene, S. McBrinn, S. Beatty, S. Beatty; Changes in Macular Pigment Optical Density and Serum Concentrations of Its Constituent Carotenoids in Responce to Weight Loss. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1289. doi: https://doi.org/.
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To investigate if weight loss is associated with changes in serum concentrations of lutein (L) and zeaxanthin (Z), and/or macular pigment optical density (MPOD).
We recruited 104 overweight subjects into this randomised-controlled weight loss study. Weight was assessed weekly and body composition, including BMI (kg/m2) and body fat (kg and percentage body fat) were assessed at baseline, six, and 12 months. Weight loss was achieved using dietary and exercise programmes. MPOD was measured by heterochromatic flicker photometry and serum concentrations of L and Z by HPLC (at baseline, one, three, six, and 12-months). The control (C) group were assessed at baseline and 12-months.
Repeated measures analysis of variance (RMA) demonstrated significant weight loss in the I group over the study period (p = 0.000). There was no significant weight change in the C group (p = 0.993). RMA of dietary L and Z, serum L and Z, and MPOD demonstrated no significant time, or time/group interaction, effect in any of these parameters (p > 0.05, for all), with the exception of a significant decrease in dietary intake of Z seen in both groups (p < 0.05). There was a positive and significant relationship between body fat loss (kg) and increase in serum concentrations of L in the I group (r = 0.521, p = 0.006).
Our finding that a reduction in fat mass (kg) is related to increases in serum concentrations of L is consistent with the hypothesis that body fat acts as a reservoir for this carotenoid.
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