April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Changes in Macular Pigment Optical Density and Serum Concentrations of Its Constituent Carotenoids in Responce to Weight Loss
Author Affiliations & Notes
  • J. M. Nolan
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
  • M. L. Kirby
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
  • J. Stack
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
  • M. Harrison
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
  • I. Greene
    Department of Dietetics, Waterford Regional Hospital, Waterford, Ireland
  • S. McBrinn
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
  • S. Beatty
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
  • S. Beatty
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
  • Footnotes
    Commercial Relationships  J.M. Nolan, None; M.L. Kirby, None; J. Stack, None; M. Harrison, None; I. Greene, None; S. McBrinn, None; S. Beatty, None; S. Beatty, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1289. doi:https://doi.org/
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      J. M. Nolan, M. L. Kirby, J. Stack, M. Harrison, I. Greene, S. McBrinn, S. Beatty, S. Beatty; Changes in Macular Pigment Optical Density and Serum Concentrations of Its Constituent Carotenoids in Responce to Weight Loss. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1289. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate if weight loss is associated with changes in serum concentrations of lutein (L) and zeaxanthin (Z), and/or macular pigment optical density (MPOD).

Methods: : We recruited 104 overweight subjects into this randomised-controlled weight loss study. Weight was assessed weekly and body composition, including BMI (kg/m2) and body fat (kg and percentage body fat) were assessed at baseline, six, and 12 months. Weight loss was achieved using dietary and exercise programmes. MPOD was measured by heterochromatic flicker photometry and serum concentrations of L and Z by HPLC (at baseline, one, three, six, and 12-months). The control (C) group were assessed at baseline and 12-months.

Results: : Repeated measures analysis of variance (RMA) demonstrated significant weight loss in the I group over the study period (p = 0.000). There was no significant weight change in the C group (p = 0.993). RMA of dietary L and Z, serum L and Z, and MPOD demonstrated no significant time, or time/group interaction, effect in any of these parameters (p > 0.05, for all), with the exception of a significant decrease in dietary intake of Z seen in both groups (p < 0.05). There was a positive and significant relationship between body fat loss (kg) and increase in serum concentrations of L in the I group (r = 0.521, p = 0.006).

Conclusions: : Our finding that a reduction in fat mass (kg) is related to increases in serum concentrations of L is consistent with the hypothesis that body fat acts as a reservoir for this carotenoid.

Keywords: macular pigment • age-related macular degeneration • nutritional factors 
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