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S. K. West, B. E. Munoz, H. Mkocha, M. Wolle, C. Gaydos, T. Quinn; Secular Changes in Trachoma in a Hyperendemic Community in Tanzania. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1315.
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To evaluate changes over time in trachoma by age group in a hyper-endemic village in Kongwa, Tanzania.
Cross sectional studies for trachoma and ocular C. trachomatis infection on all children in this village have been carried out at baseline, 2, 6, 12, 18 months, and 60, 72, 78, and 84 months post baseline. Clinical grading of follicular trachoma (TF), inflammatory trachoma (TI), and scarring trachoma (TS) were done based on photographs, using the WHO simplified grading scheme. Mass treatement with azithromycin was offered at baseline, 18 months, 60 months, and 72 months post baseline.
At baseline, trachoma was 60% in children ages 5 and under. After the initial round of mass treatment, trachoma and infection declined, and never again reached pre-treatment levels. After the gap between 18 months and 60 months, re-emergence occurred but not to pre-treatment levels, instead trachoma was consistently around 30%. The increased rate of scarring in 11-15 year olds, predicted to be at 35% from a previous model, does not appear to have occurred by 84 months.
Trachoma appears to be declining in this formerly hyper-endemic community.
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