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M. Reibaldi, A. Reibaldi, T. Avitabile, M. G. Uva, F. Boscia, L. Motta, M. Zagari, A. Longo; Choroidal Thickness in Eyes With Idiopathic Macular Hole. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1323.
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to measure macular choroidal thickness in eyes with idiopathic macular hole, compared to unaffected fellow eyes and healthy control eyes.
In a cross-sectional prospective study, 22 patients with a full thickness idiopathic macular hole in one eye, and 22 age-sex matched eyes were recruited. Patients with axial length >26 mm, , glaucoma, any chorio-retinal pathology, previous ocular surgery, uncontrolled diabetes or hypertension, or treated with alpha or beta-blockers, sildenafil, corticosteroids were excluded.Best corrected visual acuity (by the modified EDTRS charts at 2 m), the minimum diameter of the hole by HRA2 Spectralis (Heidelberg Engineering, Heidelberg, Germany), and the axial length (by A-scan ultrasonography) were determined. Choroidal thickness was measured by using HRA2 Spectralis. An inverted image was obtained by positioning the camera close to the eye. Seven horizontal sections are performed in a rectangular area encompassing the macula, and the section going through the center of the fovea was selected. The choroidal thickness was measured from the outer portion of the hyperreflective line corresponding to the RPE to the inner surface of the sclera. Measurements of the subfoveal choroid and at 1000-µm and 2000-µm nasal and temporal from the center of the fovea were performed.
At all location, a significant difference in choroidal thickness was seen among the three groups (ANOVA p<0.001); choroidal thickness was significantly lower in eyes with idiopathic macular hole and in fellow unaffected eyes as compared to control group (Tukey-Kramer p<0.01); no difference was seen between macular hole group and fellow eye group (Tukey-Kramer ns). Mean subfoveal choroidal thickness was 183± 42 µm in macular hole group, 197±46 µm in fellow eyes group and 245±53 µm in control group. A negative correlation between choroidal thickness and axial length was found in all groups [(macular hole (r=-0.53, p=0.01), fellow eyes (r=-0.56, p=0.018), controls (r=-0.522, p=0.018)]; in controls eyes a negative correlation was found between choroidal thickness and age (r=-0.475, p=0.026).
Choroidal thickness was reduced in patients with idiopatic macular hole, also in fellow unaffected eye. This could suggest a role of choroid in pathogenesis of idiopatic macular hole.
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