Purchase this article with an account.
J. E. Kim, R. Kapur, T.-G. Lee, J. Oswald, D. V. Weinberg; Treatment of Chronic Central Serous Chorioretinopathy With Photodynamic Therapy: Comparison of Steroid Associated and Idiopathic CSR. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1330.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To determine the response of neurosensory detachments (NSD) in chronic central serous chorioretinopathy (CSR) to photodynamic therapy (PDT) and to compare the treatment response in patients with history of steroid use (S) to those without steroid use (NS).
Retrospective chart review of patients who received PDT for management of CSR was performed. Primary outcome was resolution of NSD by optical coherence tomography (OCT). Secondary outcomes were improvement in central foveal thickness (CFT), central 1mm macular thickness (CMT), and logmar visual acuity (LogVA). These parameters were evaluated at 3 months (mo), 6 mo, and final visit following PDT. Fisher exact and Mann Whitney U tests were performed to compare binary and continuous data variables respectively.
There were total of 15 eyes of 15 patients. Preoperative data were as follows: mean LogVA = 0.52, mean CFT=284.1 um, mean CMT= 301.1 um and mean duration of disease was 52 months. After PDT, mean follow-up was 12 months. Improvement with resolution of NSD was noted at 3 mo, 6 mo, and final visit (p= 0.001-0.003) following PDT. A significant improvement was also noted in CMT (p=0.018-0.043) and CFT (p=0.018-0.043) at 3 mo, 6 mo and final visit. No significant improvement in LogVA was noted at 3 mo, 6 mo or final visit. Among 15 patients, there were 9 patients in group S and 6 patients in group NS. Both groups were balanced with regards to preoperative LogVA (NS=0.52, S=0.62), preoperative CFT (NS=290.8 um, S=280.8 um), CMT (NS=305.5 um, S=298.9 um), average duration of symptoms prior to treatment (N=46 mos, S=55 mos), average age at treatment (N=57 years, S=54 years), and gender distribution. However, there was no statistically significant difference in response to treatment between the two groups at any time point.
PDT is a reasonable treatment option for NSD in chronic CSR, resulting in anatomic improvement. No significant change in VA may be due to chronicity of the disease in this study or there may be a ceiling effect. History of steroid use may not adversely affect treatment outcome with PDT.
This PDF is available to Subscribers Only