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D. Husain, N. Shah, G. Abedi, G. R. Blaha, S. Ness; Low Fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1332.
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To study the efficacy of low fluence photodynamic therapy (PDT) on chronic central serous chorioretinopathy (CSCR).
This is a retrospective chart review of ten patients with chronic CSCR treated by low fluence PDT (300mW/cm2) at Lahey Clinic and Boston University Medical Center. Average visual acuity (Va) was computed and two tailed T-test was performed to analyze pre-treatment and post-treatment Va and optical coherence (OCT) measurements.
The mean age (+/- standard deviation (SD)) was 46 +/- 6 years. Nine patients were males with at least two confirmed history of steroid use. Mean duration of the symptoms (+/-SD) was 13.1 +/- 20.4 months. The average baseline logMAR Va was 0.606 (Snellen equivalent of 20/80) and the average post PDT treatment logMAR Va was 0.22 (Snellen equivalent: 20/33). There was a significant improvement in post-treatment visual acuity (p-value 0.038). Patients’ average pre-treatment OCT measurements were 382.2 +/-132.5 compared to post-treatment OCT measurements of 207.7 +/- 47.9 (p-value: 0.003). Patients’ average follow-up was eleven months with the minimum follow-up of four months and maximum follow-up of 24 months. All patients retained their post-treatment visual acuity.
All ten patients showed a significant improvement in visual acuity and also had significant reduction on OCT measurements after treatment. None of the patients reported major side effects from the treatment. In addition all patients continued to have excellent vision throughout the follow-up period. Low Fluence PDT is a safe and effective treatment of chronic central serous chorioretinopathy.
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