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T. Caporossi, G. D'Amico, M. Pagliara, F. Molle, D. Lepore, F. Focosi, E. Balestrazzi; Low-Fluence Photodynamic Therapy In Longstanding Chronic Central Serous Chorioretinopathy With Foveal and Gravitational Atrophy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1349.
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To describe anatomic and functional outcomes in 10 patients with long-standing severe chronic central serous chorioretinopathy (CSC) with foveal and gravitational atrophy treated with low-fluence photodynamic therapy (PDT).
10 patients with a history of over 2 years of chronic CSC and development of gravitational tracts, were treated with PDT guided by indocyanine green angiography (ICGA) with a fluence of 25 J/cm2 at an irradiance of 300 mW. Follow-up examinations 1, 3, 6 and 9 months after therapy included measurement best-corrected visual acuity (BCVA) with ETDRS test, fundus biomicroscopy, fluorescein angiography (FA) and indocyanine green angiography (ICG), optical coherence tomography (OCT spectral domain).
At 1 and 9 months after low-fluence PDT, complete resolution of subretinal and intraretinal fluid was observed in all patients. An increase in visual acuity of 36 letters in ETDRS chart was observed in all eyes after only 1 month after treatment. Mean volume reduction was 1,2 mm3 after 3 months. No treatment-related side effects were seen.
ICG-guided low-fluence PDT seems effective and safe for treating long-standing chronic CSC.
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