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M. J. Lopez-Miranda, D. Robles-Camarillo, L. Niño de Rivera y Oyarzaval, A. Zavala-Ayala, C. Cortes-Alcocer, F. Hernandez-Miranda, H. Quiroz-Mercado; Transcorneal Electrical Stimulation in Patients With Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1356.
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To describe the effect of transcorneal electrical stimulation (TES) in the best corrected visual acuity (BCVA), visual field and electrophysiological response in patients with retinitis pigmentosa (RP).
Descriptive, experimental, prospective study. Patients with clinical diagnosis of RP, with BCVA of 20/200 or better, who were treated with TES therapy were included. We performed a complete ophthalmological examination, BCVA, visual field (Humphrey visual field, Carl Zeiss Meditec Dublin USA) and electroretinogram (ERG) assessment at base line. The TES was delivered by a monopolar contact lens electrode every week for one hour for 30 weeks. Follow-up appointments were performed every week and the studies were repeated every 5 weeks since baseline.
Twelve patients were included, 5 males, 7 females, Ages ranging from 21 to 73 years-old. Eight patients were diagnosed with classic RP and 4 with Usher syndrome. After stimulation, there was no change in ERG. A minimal increase in visual field was observed. BCVA increased 10 (range) letters but the change was not significant.
Transcorneal electrical stimulation in eyes of patients with RP resulted in a slightly improved visual field and BCVA, although the change was not statistically significant we propose this treatment to prevent a decrease of best correct visual acuity.
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