April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Measurement of Retinal Nerve Fiber Layer Thickness on Retinitis Pigmentosa Patients With GDxECC
Author Affiliations & Notes
  • M. Wang
    Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai, China
  • K. Xue
    Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai, China
  • G. Xu
    Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai, China
  • X. Huang
    Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai, China
  • X. Sun
    Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai, China
  • Footnotes
    Commercial Relationships  M. Wang, None; K. Xue, None; G. Xu, None; X. Huang, None; X. Sun, None.
  • Footnotes
    Support  National Basic Research Program of China 2007CB512204; National Science Foundation of China 30600696
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1370. doi:
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    • Get Citation

      M. Wang, K. Xue, G. Xu, X. Huang, X. Sun; Measurement of Retinal Nerve Fiber Layer Thickness on Retinitis Pigmentosa Patients With GDxECC. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1370.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To observe the thickness of the retinal nerve fiber layer (RNFL) on patients of retinitis pigmentosa (RP) and normal controls measured with GDxECC

Methods: : 20 eyes from 10 RP patients and 40 eyes 20 normal subjects were included. GDxECC(Laser Diagnostic Technologies, Ltd., San Diego, CA) measured the thickness of RNFL in the peripapillary area in all subjects. TSNIT parameters including TSNIT average, superior average, inferior average, TSNIT standard deviation, inter-eye symmetry and NFI were obtained with GDxECC.

Results: : For GDxECC in RP patients and controls, TSNIT averages were 66.17±5.78 and 56.92±4.72. Superior averages were 81.66±8.76 and 70.81±7.32. Inferior averages were 83.06±8.67 and 68.34±6.89. TSNIT standard deviations were 28.72±5.22 and 24.65±4.11. Inter-eye symmetries were 0.85±0.11 and 0.87±0.09. NFIs were 8.17±8.10 and 16.74±8.05. The difference of TSNIT average, superior average, inferior average, TSNIT standard deviation and NFI had statistical significance (p<0.001).

Conclusions: : The thickness of RNFL measured with GDxECC was significantly thicker in RP patients than in controls. The results provide the RNFL thickness information for investigating the mechanism of this phenomenon. 1. Hood et al IOVS (2009); 2. Walia and Fishman IOVS (2008)

Keywords: retinal degenerations: hereditary • nerve fiber layer • imaging/image analysis: clinical 
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