April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Psychophysics and ERG Findings in a Group of Retinitis Pigmentosa Patients
Author Affiliations & Notes
  • L. B. Lima
    Instituto de Ciencias Biologicas,
    Nucleo de Medicina Tropical,
    Universidade Federal do Para, Belem, Brazil
  • B. D. Gomes
    Instituto de Ciencias Biologicas,
    Nucleo de Medicina Tropical,
    Universidade Federal do Para, Belem, Brazil
  • G. S. Souza
    Instituto de Ciencias Biologicas,
    Nucleo de Medicina Tropical,
    Universidade Federal do Para, Belem, Brazil
  • M. G. Lima
    Instituto de Ciencias Biologicas,
    Nucleo de Medicina Tropical,
    Universidade Federal do Para, Belem, Brazil
  • A. R. Rodrigues
    Nucleo de Medicina Tropical,
    Universidade Federal do Para, Belem, Brazil
  • L. L. Silveira
    Instituto de Ciencias Biologicas,
    Nucleo de Medicina Tropical,
    Universidade Federal do Para, Belem, Brazil
  • Footnotes
    Commercial Relationships  L.B. Lima, None; B.D. Gomes, None; G.S. Souza, None; M.G. Lima, None; A.R. Rodrigues, None; L.L. Silveira, None.
  • Footnotes
    Support  CNPq, CAPES, and FINEP IBN-Net
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1374. doi:
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      L. B. Lima, B. D. Gomes, G. S. Souza, M. G. Lima, A. R. Rodrigues, L. L. Silveira; Psychophysics and ERG Findings in a Group of Retinitis Pigmentosa Patients. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1374.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Retinitis pigmentosa (RP) is group of inherited retinal diseases that affect photoreceptors and retinal pigment epithelium. The RP patients are known to have impaired electroretinogram and behavioral studies also reported low ability in visual tasks. We evaluated RP patients assessing the retinal function by thresholds estimated with different psychophysical procedures and full-field electroretinography (ffERG) recorded in scotopic and photopic condition.

Methods: : Subjects were divided in three groups. Control group: ffERG, n = 18, 8 males and 10 females, 27 ± 3.2 years old; psychophysics, n = 68, 32 males and 36 females, 34 ± 2.6 years old. RP family group: ffERGs, n = 15, 11 males and 4 females, 36 ± 11.3 years old; psychophysics, n = 18, 8 males and 10 females, 37.2 ± 13.7 years old. RP group: ffERGs, n = 9, 3 males and 6 females, 32.8 ± 3.7 years old. Because of the severity of the visual losses, visual acuity from RP group subjects was not sufficient to perform psychophysical test. Psychophysics stimuli were presented in a CRT monitor and comprised the following methods: Farnsworth-Munsell FM-100 test, luminance spatial and temporal contrast sensitivity. ffERG stimuli were flashes presented in a ganzfeld to measure the following conditions: scotopic, dark-adapted rod response (0.03 cd/m2) and dark-adapted rod-cone response (3 cd/m2); photopic, light-adapted (3 cd/m2). For the three conditions, b-wave amplitude was measured from a-wave trough to b-wave peak. Implicit times from the time of the flash to the peak of the b-wave were also measured. A comparison was then applied among RP group, RP family group and control group.

Results: : Psychophysical visual evaluation showed that asymptomatic RP carriers performed worse than healthy controls (one tailed t test, p < 0.05) in all tests (FM-100, spatial and temporal luminance contrast sensitivity). ffERGs from RP group were not recorded in all patients for both conditions, scotopic and photopic. ffERGs family group was significantly different from control group for mixed rod-cone responses (one tailed t test, p < 0.05).

Conclusions: : Retinitis pigmentosa strongly affects visual acuity and ffERGs waves. Asymptomatic subjects from the RP family group show behavioral and electrophysiology abnormalities when compared with healthy controls. Careful psychophysical and electrophysiological follow up of RP family members might provide useful insight on this disease.

Keywords: retinitis • contrast sensitivity • electroretinography: non-clinical 
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