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J. C. Hwang, L. H. Lima, N. K. Wang, K. B. Freund, L. A. Yannuzzi, S. H. Tsang; Fundus Autofluorescence in Late-Onset Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1379.
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To demonstrate the utility of fundus autofluorescence in late-onset retinitis pigmentosa.
Retrospective case series. Patients diagnosed with late-onset retinitis pigmentosa were identified retrospectively in an institutional setting. Twelve eyes of six patients were identified and medical records were reviewed.
All patients presented with slowly progressive peripheral field loss and initial clinical examination revealed only subtle retinal changes. All patients underwent magnetic resonance imaging of the brain to rule out intracranial processes and many were referred to various subspecialties for further evaluation. Fundus autofluorescence was ultimately employed in all patients and revealed more extensive retinal pathology than initially appreciated on clinical examination. Fundus autofluorescence directed the workup toward a retinal etiology in all cases and led to the eventual diagnosis of late-onset retinitis pigmentosa through electroretinogram testing.
Fundus autofluorescence may be a more sensitive marker for retinal pathology than clinical examination alone in late-onset retinitis pigmentosa. Early use of fundus autofluorescence in the evaluation of patients with subtle retinal lesions and complaints of peripheral field loss may be an effective strategy for timely and cost-efficient diagnosis.
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