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T. Fujiwara, Y. Imamura, V. J. Giovinazzo, R. F. Spaide; Fundus Autofluorescence and Optical Coherence Tomographic Findings in Acute Zonal Occult Outer Retinopathy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1383. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the fundus autofluorescence (FAF) and optical coherence tomography (OCT) findings in eyes with acute zonal occult outer retinopathy (AZOOR).
A retrospective observational case series of the FAF and spectral domain OCT in a series of patients with AZOOR diagnosed as originally reported by Gass. The OCTs were evaluated for photoreceptor layer thickness, choroidal thickness, and retinal architecture, and compared to a group of 61 normal eyes.
There were 19 eyes of 11 patients (10 females), who had a mean age of 49.1±13.9 years. FAF abnormalities were seen in 17 of the 19 eyes, were more common in the peripapillary area and were smaller in extent than the OCT abnormalities. Nine eyes showed progression of hypoautofluorescence area during the mean follow-up of 69.7 months. Seventeen of 19 eyes had a Central Retinal Artery Equivalent diameter less than the normal range. The mean thickness of photoreceptor layer in the central fovea was 177 µm in eyes with AZOOR, which was significantly thinner than controls (193µm, P= 0.049) and the differences between eyes with AZOOR and normal eyes were more evident outside of the fovea. Abnormal retinal lamination including hyperreflective aggregates within the inner nuclear layer and hyporeflective bands in ganglion cell layer were found in 12 eyes and were located over areas of loss of the photoreceptors. The subfoveal choroidal thickness was 243 µm, which is normal.
FAF abnormalities in AZOOR showed distinct patterns of retinal pigment epithelial involvement, which may be progressive. Thinning of photoreceptor cell layer with loss of the outer segments, and abnormal inner retinal lamination in the context of a normal choroid are commonly found in AZOOR.
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