Purchase this article with an account.
M. Storoni, A. Petzold, G. T. Plant; The Epidemiological Profile of Patient Cohort With Isolated Optic Neuritis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1467.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
This study provides an epidemiological profile of patients presenting with isolated optic neuritis in London, and uncovers population-based predispositions to various optic neuritis subtypes.
We have recently described the incidence of NMO IgG seropositivity in a cohort of 102 patients who presented to our hospital with isolated idiopathic optic neuritis. Of these patients, 21% were diagnosed with neuromyelitis optica (NMO), 22% were diagnosed with multiple sclerosis related optic neuritis (MS-ON) and the remainder fell into one of three categories: chronic relapsing inflammatory optic neuropathy (CRION, 18%), relapsing isolated optic neuritis (RION, 12%) and a single episode of optic neuritis with evidence of neither MS nor NMO (non-MS ON, 28%). In this paper we explore the epidemiological profile of the same patient cohort, and examine any population-based predispositions to any of the above optic neuritis categories.
94% of our patient cohort belonging to the MS-ON group was white, compared to 24% of the NMO group. Our results show a population variation in the susceptibility to CRION, RION and non-MS ON. RION sufferers were found to be predominantly white (67%) whereas the majority of CRION patients were Asian (43%) and African-Caribbean (43%). Although the majority of non-MS ON patients are white (63%) the second largest group affected is Asian (42%).
Our findings suggest that an Asian patient who presents with isolated idiopathic optic neuritis has a high likelihood of being diagnosed either with non-MS ON (40%) or with CRION (30%). An African Caribbean patient presenting with isolated idiopathic optic neuritis has a strong chance of developing NMO (42%) and a lesser chance of developing CRION (23%), whereas patients from both ethnic groups are far less likely to suffer from MS-ON and RION. Similarly, in a white patient, this presentation is likely to be a sign of multiple sclerosis (36%).These observations have wide ranging implications on patients’ treatment profiles and provide a case for immunosuppressive therapy at the point of presentation for patients of African Caribbean and Asian backgrounds, who present with idiopathic isolated optic neuritis.
This PDF is available to Subscribers Only